1-溴-2-苯基乙炔-苯合成路线 （共 49 条）
反应条件
1: With titanium tetrachloride; tert-butylamine in toluene T=120°C; 22 h; 2: With hydrogenchloride in toluene T=100°C; 24 h; Further stages. Title compound not separated from byproducts.;
参考文献
Ackermann, Lutz; Kaspar, Ludwig T.
Journal of Organic Chemistry, 2007 , vol. 72, # 16 p. 6149 - 6153
反应条件
1: With titanium tetrachloride; tert-butylamine in toluene T=120°C; 22 h; 2: With hydrogenchloride in toluene T=100°C; 24 h; 3: With potassium phosphate; copper(l) iodide in N,N-dimethyl-formamide T=105°C; 22 h; Further stages.;
参考文献
Ackermann, Lutz; Kaspar, Ludwig T.
Journal of Organic Chemistry, 2007 , vol. 72, # 16 p. 6149 - 6153
反应条件
1: With titanium tetrachloride; tert-butylamine in toluene T=120°C; 22 h; 2: With hydrogenchloride in toluene T=100°C; 24 h; Further stages. Title compound not separated from byproducts.;
参考文献
Ackermann, Lutz; Kaspar, Ludwig T.
Journal of Organic Chemistry, 2007 , vol. 72, # 16 p. 6149 - 6153
反应条件
tri-tert-butyl phosphine; potassium tert-butylate; palladium diacetate in toluene T=110 - 120°C; 14 h;
参考文献
DALHOUSIE UNIVERSITY; STRADIOTTO, Mark John
Patent: WO2013/159229 A1, 2013 ;
Location in patent: Paragraph 00107-00111; 00124; 00125 ;
反应条件
1: 1-(2-bromophenyl)-2-phenylacetylene With t-Bu-BippyPhos; [Pd(η3-1-Ph-allyl)(μ-Cl)]2; potassium tert-butylate; ammonia in 1,4-dioxane T=110°C; Buchwald-Hartwig Coupling; 8 h; Inert atmosphereGlovebox; 2: chlorobenzene With t-Bu-BippyPhos; [Pd(η3-1-Ph-allyl)(μ-Cl)]2; sodium t-butanolate in toluene T=110°C; Buchwald-Hartwig Coupling; 12 h; Inert atmosphereGlovebox;
参考文献
Crawford, Sarah M.; Lavery, Christopher B.; Stradiotto, Mark
Chemistry - A European Journal, 2013 , vol. 19, # 49 p. 16760 - 16771
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; cesium fluoride in 1,4-dioxane
T=60 - 70°C;
参考文献
Levi, Zerubba U.; Tilley, T. Don
Journal of the American Chemical Society, 2009 , vol. 131, p. 2796 - 2797
反应条件
Na2S*9H2O in 1-methyl-pyrrolidin-2-one
T=80°C; 6 h; Inert atmosphere;
参考文献
Li, Yaming; Nie, Caiping; Wang, Huifeng; Li, Xiaoying; Verpoort, Francis; Duan, Chunying
European Journal of Organic Chemistry, 2011 , # 36 p. 7331 - 7338
反应条件
t-Bu-BippyPhos; tris-(dibenzylideneacetone)dipalladium(0); cesium hydroxide monohydrate in 1,4-dioxane
T=110°C; 12 h; Inert atmosphereGloveboxSealed tube;
参考文献
Lavery, Christopher B.; Rotta-Loria, Nicolas L.; McDonald, Robert; Stradiotto, Mark
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 5 p. 981 - 987
反应条件
1: With titanium tetrachloride; tert-butylamine in toluene
T=120°C; 22 h;
2: With hydrogenchloride in toluene
T=100°C; 24 h;
3: With potassium phosphate; copper(l) iodide in N,N-dimethyl-formamide
T=105°C; 22 h; Further stages.;
参考文献
Ackermann, Lutz; Kaspar, Ludwig T.
Journal of Organic Chemistry, 2007 , vol. 72, # 16 p. 6149 - 6153
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; caesium carbonate; hydroquinone; cesium fluoride in 1,4-dioxane
T=135°C; 24 h;
参考文献
Levi, Zerubba U.; Tilley, T. Don
Journal of the American Chemical Society, 2009 , vol. 131, p. 2796 - 2797
