1-溴-2-苯基乙炔-苯合成路线 （共 49 条）
反应条件
1.1: n-BuLi / diethyl ether; various solvent(s) / 1 h / -78 °C 1.2: I2 / diethyl ether; various solvent(s) / -78 - 15 °C 2.1: 0.659 g / Pd(PPh3)2Cl2; CuI; Et3N / 1 h / 20 °C 3.1: 97 percent / NaOH / methanol View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 23 p. 7804 - 7810
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in tetrahydrofuran Sonogashira coupling; 11 h; Inert atmosphereReflux; 2: With tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 4.5 h;
参考文献
Advanced Synthesis and Catalysis, , vol. 352, # 2-3 p. 368 - 372
反应条件
CyPF-tBu; [Pd(η3-1-Ph-allyl)(μ-Cl)]2; potassium tert-butylate; hydrazine hydrate in 1,4-dioxane T=90°C; 1 h; Inert atmosphere;
参考文献
Alsabeh, Pamela G.; Lundgren, Rylan J.; Longobardi, Lauren E.; Stradiotto, Mark
Chemical Communications, 2011 , vol. 47, # 24 p. 6936 - 6938
反应条件
1.1: tert.-butyl lithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 1.2: -78 - 20 °C / Inert atmosphere 2.1: hydrogenchloride; water / acetone / 1 h / 20 °C / Inert atmosphere View Scheme
参考文献
Katsumoto, Kenta; Kitamura, Chitoshi; Kawase, Takeshi
European Journal of Organic Chemistry, 2011 , # 25 p. 4885 - 4891
反应条件
1: 1-(2-bromophenyl)-2-phenylacetylene With tert.-butyl lithium in tetrahydrofuran T=-78°C; 0.5 h; Inert atmosphere; 2: 4-benzoylpiperidine in tetrahydrofuran T=-78 - 20°C; Inert atmosphere; 3: With hydrogenchloride; water in acetone T=20°C; 1 h; Inert atmosphere;
参考文献
Katsumoto, Kenta; Kitamura, Chitoshi; Kawase, Takeshi
European Journal of Organic Chemistry, 2011 , # 25 p. 4885 - 4891
反应条件
[Pd(η3-1-Ph-allyl)(μ-Cl)]2; C35H55OPSi; potassium tert-butylate in toluene T=90°C; Buchwald-Hartwig Coupling; 12 h; Inert atmosphereSealed tube; Reagent/catalyst;
参考文献
DALHOUSIE UNIVERSITY; STRADIOTTO, Mark John
Patent: WO2013/159229 A1, 2013 ;
Location in patent: Paragraph 00206-00208 ;
反应条件
palladium diacetate; (S)-(-)-2-methyl-2-propanesulfinamide; caesium carbonate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,4-dioxane T=100°C; 15 h; Inert atmosphere;
参考文献
Prakash, Anjanappa; Dibakar, Mullick; Selvakumar, Kumaravel; Ruckmani, Kandasamy; Sivakumar, Manickam
Tetrahedron Letters, 2011 , vol. 52, # 43 p. 5625 - 5628
反应条件
[Pd(η3-1-Ph-allyl)(μ-Cl)]2; C38H61O4PSi; potassium tert-butylate in toluene T=90°C; Buchwald-Hartwig Coupling; 12 h; Inert atmosphereSealed tube; Reagent/catalyst;
参考文献
DALHOUSIE UNIVERSITY; STRADIOTTO, Mark John
Patent: WO2013/159229 A1, 2013 ;
Location in patent: Paragraph 00206-00208 ;
反应条件
1: With copper(l) iodide; potassium carbonate; N-methyl-2-(methylamino)ethylamine in toluene T=105°C; 24 h; Inert atmosphere; 2: With trifluoroacetic acid in dichloromethane T=23°C; 2 h; Inert atmosphere;
参考文献
Ackermann, Lutz; Barfuesser, Sebastian; Potukuchi, Harish K.
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 7-8 p. 1064 - 1072
反应条件
1: 1-(2-bromophenyl)-2-phenylacetylene With tert.-butyl lithium in tetrahydrofuran T=-78°C; 0.5 h; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-78 - 20°C; Inert atmosphere; 3: With hydrogenchloride; water in acetone T=20°C; 1 h; Inert atmosphere;
参考文献
Katsumoto, Kenta; Kitamura, Chitoshi; Kawase, Takeshi
European Journal of Organic Chemistry, 2011 , # 25 p. 4885 - 4891
