5-[(3-甲氧基苯基氨基)亚甲基]-2,2-二甲基-1,3-二噁烷-4,6-二酮合成路线 （共 11 条）
反应条件
1: 2,2-Dimethyl-[1,3]dioxane-4,6-dione; orthoformic acid triethyl ester in ethanol T=90°C; 1 h; 2: 3-methoxy-aniline in ethanol T=90°C; 2 h;
参考文献
Nsumiwa, Samkele; Kuter, David; Wittlin, Sergio; Chibale, Kelly; Egan, Timothy J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3738 - 3748
反应条件
in acetonitrile T=20°C; 0.25 h;
参考文献
Hill, Lawrence; Imam, S. Haider; McNab, Hamish; O'Neill, William J.
Synlett, 2009 , # 11 p. 1847 - 1851
反应条件
in acetonitrile 2 h; Heating / reflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2003/99274 A1, 2003 ;
Location in patent: Page 512-513 ;
WO 03/099274 A1
参考文献
Zicane; Ravina; Tetere; Rijkure; Petrova; Kalejs
Chemistry of Heterocyclic Compounds, 2002 , vol. 38, # 7 p. 840 - 845
反应条件
in diphenylether; biphenyl T=220°C; 1.5 h;
参考文献
KIRIN BEER KABUSHIKI KAISHA
Patent: EP1724268 A1, 2006 ;
Location in patent: Page/Page column 46 ;
反应条件
T=160 - 600°C; P=0.0142514 Torr; 1 h; Inert atmosphereFlash vacuum pyrolysis; regioselective reaction;
参考文献
Hill, Lawrence; Imam, S. Haider; McNab, Hamish; O'Neill, William J.
Synlett, 2009 , # 11 p. 1847 - 1851
反应条件
1: diphenylether / 0.08 h / |Reflux 2: trichlorophosphate / 0.33 h / 140 °C View Scheme
参考文献
Nsumiwa, Samkele; Kuter, David; Wittlin, Sergio; Chibale, Kelly; Egan, Timothy J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3738 - 3748
反应条件
T=160 - 600°C; P=0.0142514 Torr; 1 h; Inert atmosphereFlash vacuum pyrolysis; regioselective reaction;
参考文献
Hill, Lawrence; Imam, S. Haider; McNab, Hamish; O'Neill, William J.
Synlett, 2009 , # 11 p. 1847 - 1851
反应条件
1: diphenylether / 0.08 h / |Reflux 2: trichlorophosphate / 0.33 h / 140 °C 3: ammonium hydroxide; zinc(II) chloride / 1.5 h / 160 - 180 °C / 15376.5 Torr / |Microwave irradiation View Scheme
参考文献
Nsumiwa, Samkele; Kuter, David; Wittlin, Sergio; Chibale, Kelly; Egan, Timothy J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3738 - 3748
反应条件
in diphenylether T=225 - 260°C; 0.0833333 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/134378 A1, 2006 ;
Location in patent: Page/Page column 56 ;
WO 2006/134378 A1
