4-羟基-1-苯基吡唑并[3,4-D]嘧啶合成路线 （共 29 条）
反应条件
1: H2O / 7 h / Heating 2: 0.17 h / 300 °C View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 6 p. 1239 - 1262
反应条件
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C
1.2: tetrahydrofuran / 1 h / 20 °C
2.1: dimethylformamide / 2 h / Heating
View Scheme
参考文献
Tanji, Ken-ichi; Yokoi, Takeshi; Sugimoto, Osamu
Heterocycles, 2003 , vol. 60, # 2 p. 413 - 418
反应条件
potassium carbonate in ethanol
1.5 h; Heating;
参考文献
Tanji, Ken-ichi; Yokoi, Takeshi; Sugimoto, Osamu
Heterocycles, 2003 , vol. 60, # 2 p. 413 - 418
反应条件
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C
1.2: tetrahydrofuran / 1 h / 20 °C
2.1: tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Devarakonda, Murty; Doonaboina, Raghava; Vanga, Sreedher; Vemu, Jahnavi; Boni, Sathoshini; Mailavaram, Raghu Prasad
Medicinal Chemistry Research, 2013 , vol. 22, # 3 p. 1090 - 1101
反应条件
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C
1.2: tetrahydrofuran / 1 h / 20 °C
2.1: tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Tanji, Ken-ichi; Yokoi, Takeshi; Sugimoto, Osamu
Heterocycles, 2003 , vol. 60, # 2 p. 413 - 418
反应条件
1: POCl3; DMF / 4 h / Heating
2: hydrazine hydrate / ethanol / 24 h / 45 °C
View Scheme
参考文献
Peat, Andrew J.; Boucheron, Joyce A.; Dickerson, Scott H.; Garrido, Dulce; Mills, Wendy; Peckham, Jennifer; Preugschat, Frank; Smalley, Terrence; Schweiker, Stephanie L.; Wilson, Jayme R.; Wang, Tony Y.; Zhou, Huiqiang Q.; Thomson, Stephen A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2121 - 2125
反应条件
1: trichlorophosphate / 0.08 h / 120 °C / 22502.3 Torr / |Microwave irradiation
2: toluene / 20 °C
View Scheme
参考文献
Devarakonda, Murty; Doonaboina, Raghava; Vanga, Sreedher; Vemu, Jahnavi; Boni, Sathoshini; Mailavaram, Raghu Prasad
Medicinal Chemistry Research, 2013 , vol. 22, # 3 p. 1090 - 1101
反应条件
1: trichlorophosphate / 0.08 h / 120 °C / 22502.3 Torr / |Microwave irradiation
2: toluene / 20 °C
View Scheme
参考文献
Devarakonda, Murty; Doonaboina, Raghava; Vanga, Sreedher; Vemu, Jahnavi; Boni, Sathoshini; Mailavaram, Raghu Prasad
Medicinal Chemistry Research, 2013 , vol. 22, # 3 p. 1090 - 1101
反应条件
trichlorophosphate in 1,2-dichloro-ethane
T=90°C; 12 h;
参考文献
Chern, Jyh-Haur; Shia, Kak-Shan; Hsu, Tsu-An; Tai, Chia-Liang; Lee, Chung-Chi; Lee, Yen-Chun; Chang, Chih-Shiang; Tseng, Sung-Nien; Shih, Shin-Ru
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 10 p. 2519 - 2525
