1: N-methylmorpholine / dimethylformamide / 2 h / -20 °C 2: 95 percent / 1 N HCl / acetic acid / 0.5 h / Ambient temperature 3: N-methylmorpholine, hexamethylphosphoric acid triamide / dimethylformamide / 2 h / -20 °C 4: 89 percent / 1 N HCl / acetic acid / 0.5 h / Ambient temperature 5: N-methylmorpholine / dimethylformamide / 2 h / -20 °C 6: 95 percent / 1 N HCl / acetic acid / 0.5 h / Ambient temperature 7: N-methylmorpholine / dimethylformamide / 2 h / -20 °C View Scheme

1: 54.6 percent / IBCF, NMMole / dimethylformamide / -20 °C 2: TFA, anisole / CH2Cl2 / 1 h / 0 °C 3: 55 percent View Scheme

1: 54.6 percent / IBCF, NMMole / dimethylformamide / -20 °C 2: TFA, anisole / CH2Cl2 / 1 h / 0 °C View Scheme

1: 92 percent / N(C2H5)3 / dimethylformamide / 1.) 30 min., 0 deg C; 2.) 1.5 h, room temp. 2: 1.1 M HCl in acetic acid / 0.42 h / 20 °C View Scheme