L-(+)-2-氯苯甘氨酸甲酯盐酸盐合成路线 （共 6 条）
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile 8.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
HANMI PHARM. CO., LTD.
Patent: WO2005/87779 A1, 2005 ;
Location in patent: Page/Page column 23 ;
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile 8.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
HANMI PHARM. CO., LTD.
Patent: WO2005/87779 A1, 2005 ;
Location in patent: Page/Page column 23-24 ;
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile 8.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
HANMI PHARM. CO., LTD.
Patent: WO2005/87779 A1, 2005 ;
Location in patent: Page/Page column 23-24 ;
反应条件
1: 6,7-dihydro-4H-thieno[3,2-c]pyran With dibromotriphenyl-phosphorane in acetonitrile 24 h; Heating / reflux; 2: methyl (S)-2-amino-2-(2-chlorophenyl)acetate hydrochloride With N-ethyl-N,N-diisopropylamine in acetonitrile 8.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
HANMI PHARM. CO., LTD.
Patent: WO2005/87779 A1, 2005 ;
Location in patent: Page/Page column 24 ;
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile 8.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
HANMI PHARM. CO., LTD.
Patent: WO2005/87779 A1, 2005 ;
Location in patent: Page/Page column 23-24 ;
反应条件
triethylamine T=78 - 82°C; 8 - 10 h; Product distribution / selectivity;
参考文献
ORCHID CHEMICALS and PHARMACEUTICALS LIMITED
Patent: WO2007/144729 A1, 2007 ;
Location in patent: Page/Page column 5; 8 ;
