2-氯-N-苯基-丙酰胺合成路线 （共 20 条）
反应条件
sodium in ethanol T=20°C; 16 h;
参考文献
Murphy, Maureen; Lynch, Denis; Schaeffer, Marcel; Kissane, Marie; Chopra, Jay; O'Brien, Elisabeth; Ford, Alan; Ferguson, George; Maguire, Anita R.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 8 p. 1228 - 1241
反应条件
1: AlCl3, aluminium chloride / 4 h / 150 °C 2: dichloromethane / 5 h / -10 - 20 °C 3: sodium hydroxide / 10 h / |Reflux; |Inert atmosphere 4: hypophosphorous acid; hydrogenchloride; sodium nitrite / water / -7 - 20 °C 5: potassium permanganate; sulfuric acid / water / 6 h / |Reflux View Scheme
参考文献
KANDULA, Mahesh
Patent: WO2013/168003 A1, 2013 ;
反应条件
lithium aluminium tetrahydride in diethyl ether Inert atmosphereReflux;
参考文献
Vilhelmsen, Mie Hojer; stergaard, Lars Frosig; Nielsen, Mogens Brondsted; Hammerum, Steen
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 10 p. 1773 - 1778
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Inert atmosphereCooling with iceReflux;
参考文献
Vilhelmsen, Mie Hojer; stergaard, Lars Frosig; Nielsen, Mogens Brondsted; Hammerum, Steen
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 10 p. 1773 - 1778
反应条件
lithium aluminium tetrahydride in diethyl ether 20 h; Heating;
参考文献
Suzuki, Kunio; Okano, Koji; Nakai, Kiyomitsu; Terao, Yoshiyasu; Sekiya, Minoru
Synthesis, 1983 , # 9 p. 723 - 725
反应条件
lithium aluminium tetrahydride in diethyl ether Inert atmosphereReflux;
参考文献
Vilhelmsen, Mie Hojer; stergaard, Lars Frosig; Nielsen, Mogens Brondsted; Hammerum, Steen
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 10 p. 1773 - 1778
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Inert atmosphereCooling with iceReflux;
参考文献
Vilhelmsen, Mie Hojer; stergaard, Lars Frosig; Nielsen, Mogens Brondsted; Hammerum, Steen
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 10 p. 1773 - 1778
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Inert atmosphereCooling with iceReflux;
参考文献
Vilhelmsen, Mie Hojer; stergaard, Lars Frosig; Nielsen, Mogens Brondsted; Hammerum, Steen
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 10 p. 1773 - 1778
反应条件
tri-n-butyl-tin hydride; 2,2'-azo-bisisobutyronitrile in toluene 14 h; Heating;
参考文献
Helvetica Chimica Acta, , vol. 88, # 1 p. 35 - 41
反应条件
AlCl3, aluminium chloride T=150°C; 4 h;
参考文献
WO2013/168003 A1, ;
Paragraph 0094; 0095; 0096 ;
