tetrakis(triphenylphosphine) palladium(0); lithium chloride in 1,4-dioxane T=100°C; Stille coupling; 16 h; Inert atmosphere;

triphenyl phosphite; tris-(dibenzylideneacetone)dipalladium(0) in 1,4-dioxane T=100°C; Suzuki-Miyaura cross-coupling; 3 h; Inert atmosphere;

oxygen in dimethyl sulfoxide T=20°C; P=1500.15 Torr; pH=6; 24 h; aq. bufferEnzymatic reaction; regioselective reaction;

1: pyridine / dichloromethane / 3 h / 0 - 23 °C / Inert atmosphere 2: tetrakis(triphenylphosphine) palladium(0); lithium chloride / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere View Scheme

1: cesium fluoride; bis(dibenzylideneacetone)-palladium(0); tri-cyclo-hexyl-phosphine / 1,4-dioxane / 48 h / Inert atmosphere; Reflux 2: oxygen / dimethyl sulfoxide / 24 h / 20 °C / 1500.15 Torr / pH 6 / aq. buffer; Enzymatic reaction View Scheme