1-叔丁氧羰基-2-[N-甲氧基-N-甲基羰基]哌啶合成路线 （共 8 条）
反应条件
1: 1-tert-Butoxycarbonyl-piperidine-2-carboxylic acid With 1,1'-carbonyldiimidazole in dichloromethane T=20°C; 0.25 h; Inert atmosphere; 2: O,N-dimethyl-hydroxylamine hydrochloride in dichloromethane T=20°C; 15 h; Inert atmosphere;
参考文献
Kong, Chen; Jana, Navendu; Driver, Tom G.
Organic Letters, 2013 , vol. 15, # 4 p. 824 - 827
反应条件
4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide in dichloromethane T=0 - 25°C; 20.5 h;
参考文献
RICHTER GEDEON VEGYESZETI GYAR RT.
Patent: WO2007/39782 A1, 2007 ;
Location in patent: Page/Page column 23-24 ;
WO 2007/039782 A1
反应条件
N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine in dichloromethane T=20°C; 1 h;
参考文献
Sankyo Company, Limited
Patent: EP1541571 A1, 2005 ;
Location in patent: Page/Page column 95 ;
反应条件
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine in dichloromethane
参考文献
ONO PHARMACEUTICAL CO., LTD.
Patent: EP1477175 A1, 2004 ;
反应条件
1: aq. NaOH / dioxane / 20 °C 2: PyBOP; Et3N / CH2Cl2 / 20 °C View Scheme
参考文献
Kong, Chen; Jana, Navendu; Driver, Tom G.
Organic Letters, 2013 , vol. 15, # 4 p. 824 - 827
反应条件
1.1: triethylamine / 15 h / 0 - 20 °C / |Inert atmosphere 2.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.25 h / 20 °C / |Inert atmosphere 2.2: 15 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Murata, Toshiki; Shimada, Mitsuyuki; Kadono, Hiroshi; Sakakibara, Sachiko; Yoshino, Takashi; Masuda, Tsutomu; Shimazaki, Makoto; Shintani, Takuya; Fuchikami, Kinji; Bacon, Kevin B.; Ziegelbauer, Karl B.; Lowinger, Timothy B.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 15 p. 4013 - 4017
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 0.666667 h; 2: With water in tetrahydrofuran; ethyl acetate
参考文献
RICHTER GEDEON VEGYESZETI GYAR RT.
Patent: WO2007/39782 A1, 2007 ;
Location in patent: Page/Page column 24 ;
WO 2007/039782 A1
反应条件
in diethyl ether T=0°C; 1 h; Inert atmosphere;
参考文献
Organic Letters, , vol. 15, # 4 p. 824 - 827
