1-(2-氟苯基)-1-丙酮合成路线 （共 36 条）
反应条件
triethylamine tris(hydrogen fluoride); triethylamine in acetonitrile
T=80°C; 1.5 h;
参考文献
Giudicelli; Pica; Veyron
Tetrahedron Letters, 1990 , vol. 31, # 45 p. 6527 - 6530
反应条件
sodium hexamethyldisilazane; N-Fluoro-o-benzenedisulfonimide in tetrahydrofuran
1.) -78 deg C, 10 min; -78 to 0 deg C, 0.5 h, 2.) r.t., 2 h;
参考文献
Davis, Franklin A.; Han, Wei; Murphy, Christopher K.
Journal of Organic Chemistry, 1995 , vol. 60, # 15 p. 4730 - 4737
反应条件
pyridine; tetrabutyl ammonium fluoride in 1,4-dioxane
T=80°C; 24 h;
参考文献
Moughamir, Khadija; Atmani, Aziz; Mestdagh, Helene; Rolando, Christian; Francesch, Charlette
Tetrahedron Letters, 1998 , vol. 39, # 40 p. 7305 - 7306
反应条件
hydrogenchloride in dichloromethane
T=20°C; 2 h;
参考文献
Verniest, Guido; Van Hende, Eva; Surmont, Riccardo; De Kimpe, Norbert
Organic Letters, 2006 , vol. 8, # 21 p. 4767 - 4770
反应条件
4 A molecular sieve; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in acetonitrile
T=-10°C;
参考文献
Peng, Weimin; Shreeve, Jean'ne M.
Journal of Organic Chemistry, 2005 , vol. 70, # 14 p. 5760 - 5763
反应条件
lithium diisopropyl amide in tetrahydrofuran
参考文献
Schering Aktiengesellschaft
Patent: US5786474 A1, 1998 ;
反应条件
1: With iodotoluene difluoride; boron trifluoride diethyl etherate in dichloromethane
T=-78°C; 2 h;
2: With triethylamine tris(hydrogen fluoride) in dichloromethane
1 h;
参考文献
Sato, Saeko; Yoshida, Masanori; Hara, Shoji
Synthesis, 2005 , # 15 art. no. F18704SS, p. 2602 - 2605
反应条件
[{(η5-C5Me5)IrCl}2(μ-Cl)2]; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in tetrahydrofuran; water
T=30°C; 15 h; Inert atmosphere; regiospecific reaction;
参考文献
Ahlsten, Nanna; Bartoszewicz, Agnieszka; Agrawal, Santosh; Martin-Matute, Belen
Synthesis, 2011 , # 16 art. no. C57411SS, p. 2600 - 2608
反应条件
fluorine in various solvent(s)
T=-78°C; 3.5 h;
参考文献
Purrington, Suzane T.; Lazaridis, Nicholas V.; Bumgardner, Carl L.
Tetrahedron Letters, 1986 , vol. 27, # 24 p. 2715 - 2716
反应条件
1: With tri-tert-butyl phosphine; tetra-n-butylammonium difluorotriphenylsilicate(IV); bis(dibenzylideneacetone)-palladium(0) in toluene
T=95°C; Inert atmosphere;
2: With silica gel in toluene
参考文献
Guo, Yong; Tao, Guo-Hong; Blumenfeld, Alex; Shreeve, Jean'ne M.
Organometallics, 2010 , vol. 29, # 7 p. 1818 - 1823
