2-(4-苄基-1-哌嗪)甲氧基苯合成路线 （共 8 条）
反应条件
potassium carbonate in butanone T=80°C; 24 h;
参考文献
Sukalovic, Vladimir; Zlatovic, Mario; Andric, Deana; Roglic, Goran; Kostic-Rajacic, Sladjana; Soskic, Vukic
Arzneimittel-Forschung/Drug Research, 2005 , vol. 55, # 3 p. 145 - 152
反应条件
n-butyllithium in tetrahydrofuran; hexane 1.) 0 deg C, 30 min; room temp., 1 h, 2.) reflux, overnight;
参考文献
Hoeve, Wolter ten; Kruse, Chris, G.; Luteyn, Jan M.; Thiecke, Janet R. G.; Wynberg, Hans
Journal of Organic Chemistry, 1993 , vol. 58, # 19 p. 5101 - 5106
反应条件
1: 1.) N,N'-carbonyldiimidazole / 1.) THF, reflux, 15 min; 2.) THF, 16 h, reflux 2: 49 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating View Scheme
参考文献
Kruse, C. G.; Troost, J. J.; Cohen-Fernandes, P.; Linden, H. van der; Loon, J. D. van
Recueil des Travaux Chimiques des Pays-Bas, 1988 , vol. 107, # 4 p. 303 - 310
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 4 h; Heating;
参考文献
Kruse, C. G.; Troost, J. J.; Cohen-Fernandes, P.; Linden, H. van der; Loon, J. D. van
Recueil des Travaux Chimiques des Pays-Bas, 1988 , vol. 107, # 4 p. 303 - 310
反应条件
1: 83 percent / N,N'-carbonyldiimidazole / tetrahydrofuran / 16 h / 65 °C 2: 49 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating View Scheme
参考文献
Kruse, C. G.; Troost, J. J.; Cohen-Fernandes, P.; Linden, H. van der; Loon, J. D. van
Recueil des Travaux Chimiques des Pays-Bas, 1988 , vol. 107, # 4 p. 303 - 310
反应条件
in dimethyl sulfoxide
参考文献
Mewshaw, Richard E.; Husbands, Morris; Gildersleeve, Elizabeth S.; Webb, Michael B.; Shi, Xiaojie; Mazandarani, Hossein; Cockett, Mark I.; Ochalski, Rafal; Brennan, Julie A.; Abou-Gharbia, Magid; Marquis, Karen; McGaughey, Georgia B.; Coupet, Joseph; Andree, Terrance H.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 3 p. 295 - 300
反应条件
1: 1.) N,N'-carbonyldiimidazole / 1.) THF, reflux, 15 min; 2.) THF, 16 h, reflux 2: 49 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating View Scheme
参考文献
Kruse, C. G.; Troost, J. J.; Cohen-Fernandes, P.; Linden, H. van der; Loon, J. D. van
Recueil des Travaux Chimiques des Pays-Bas, 1988 , vol. 107, # 4 p. 303 - 310
反应条件
1: 86 percent / BH3*Me2S / tetrahydrofuran / Heating 2: triethylamine / tetrahydrofuran View Scheme
参考文献
Kruse, C. G.; Troost, J. J.; Cohen-Fernandes, P.; Linden, H. van der; Loon, J. D. van
Recueil des Travaux Chimiques des Pays-Bas, 1988 , vol. 107, # 4 p. 303 - 310
