Alpha-甲基-环己基乙醛合成路线 （共 22 条）
参考文献
Ferrari,G.; Casagrande,C.
Farmaco, Edizione Scientifica, 1963 , vol. 18, p. 780 - 792
参考文献
Kao Corporation
Patent: US5049544 A1, 1991 ;
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran
P=760 Torr; 15 h; Ambient temperature;
参考文献
Maruoka, Keiji; Itoh, Takayuki; Sakurai, Minoru; Nonoshita, Katsumasa; Yamamoto, Hisashi
Journal of the American Chemical Society, 1988 , vol. 110, p. 3588 - 3597
反应条件
1: With [Ir(acetylacetonate)(1,5-cyclooctadiene)]; triphenylphosphine in N-methylpyrrolidone
T=20 - 100°C; P=5250.53 Torr; Inert atmosphereAutoclave;
2: With hydrogen in N-methylpyrrolidone
T=100°C; P=9750.98 Torr; 16 h; Autoclave; chemoselective reaction;
参考文献
Evonik Oxeno GmbH; Franke, Robert; Beller, Matthias; Jackstell, Ralf; Jennerjahn, Reiko; Piras, Irene
Patent: US2014/24860 A1, 2014 ;
Location in patent: Paragraph 0087 ;
反应条件
[Pd2H2(1,3-bis(diphenylphosphino)propane)3](TfO)2 in tetrahydrofuran
T=100°C; 24 h; Schlenk techniqueInert atmosphereGlovebox;
参考文献
Mazet, Clement
Chimia, 2013 , vol. 67, # 9 p. 658 - 662
反应条件
2: 85 percent / H2 / Pd/C / tetrahydrofuran / 15 h / 760 Torr / Ambient temperature
View Scheme
参考文献
Maruoka, Keiji; Itoh, Takayuki; Sakurai, Minoru; Nonoshita, Katsumasa; Yamamoto, Hisashi
Journal of the American Chemical Society, 1988 , vol. 110, p. 3588 - 3597
反应条件
tetrafluoroboric acid; mercury(II) oxide in tetrahydrofuran
0.0833333 h; Heating;
参考文献
Ceruti, Maurizio; Degani, Iacopo; Fochi, Rita
Synthesis, 1987 , # 1 p. 79 - 82
反应条件
1.1: KO-t-Bu / CH2Cl2; 2-methyl-propan-2-ol / 5 - 25 °C
1.2: KOH / ethanol; H2O / Heating
2.1: conc. HCl / H2O / Heating
View Scheme
参考文献
Hoffmann, Sebastian; Nicoletti, Marcello; List, Benjamin
Journal of the American Chemical Society, 2006 , vol. 128, # 40 p. 13074 - 13075
反应条件
[rhodium(I)(carbonyl)2(acetylacetonate)]; triphenylphosphine-3,3',3''-trisulfonic acid trisodium salt; heptakis(2,6-di-O-methyl)-beta-cyclodextrin; hydrogen in water
T=80°C; P=38000 Torr; 2 h; stainless steel autoclave; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Monflier, Eric; Tilloy, Sebastien; Fremy, Georges; Castanet, Yves; Mortreux, Andre
Tetrahedron Letters, 1995 , vol. 36, # 52 p. 9481 - 9484
参考文献
Cram; Greene
Journal of the American Chemical Society, 1953 , vol. 75, p. 6005,6009
