2-溴-1-(4-甲氧苯基)丙酮合成路线 （共 18 条）
反应条件
bromine T=20°C; 0.333333 h;
参考文献
Lagoja, Irene M.; Pannecouque, Christophe; Van Aerschot, Arthur; Witvrouw, Myriam; Debyser, Zeger; Balzarini, Jan; Herdewijn, Piet; De Clercq, Erik
Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1546 - 1553
反应条件
aluminium trichloride in 1,2-dichloro-ethane T=0 - 20°C; Friedel-Crafts acylation; 2 h;
参考文献
Wiglenda, Thomas; Gust, Ronald
Journal of Medicinal Chemistry, 2007 , vol. 50, # 7 p. 1475 - 1484
反应条件
hydrogen bromide; bromine in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; acetic acid
参考文献
Schering Aktiengesellschaft
Patent: US6147105 A1, 2000 ;
反应条件
N-bromosuccinmide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in dimethyl sulfoxide T=25 - 35°C; 0.3 h; regioselective reaction;
参考文献
Moorthy, Jarugu Narasimha; Senapati, Kalyan; Singhal, Nidhi
Tetrahedron Letters, 2009 , vol. 50, # 21 p. 2493 - 2496
反应条件
1: AlCl3, aluminium chloride / dichloromethane / 0 - 70 °C 2: copper(ll) bromide / chloroform; ethyl acetate / 4 h / Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 54, p. 123 - 136
反应条件
aluminium trichloride; Petroleum ether T=-10 - -5°C;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 535, p. 219,248
反应条件
chromium(VI) oxide; acetic acid
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2> 52, p. 199
参考文献
Chemische Berichte, , vol. 29, p. 687
反应条件
potassium iodide in acetone 72 h; Ambient temperature;
参考文献
Bettoni, Giancarlo; Cellucci, Carla; Ferorelli, Savina; Perrone, Roberto; Tortorella, Vincenzo
Tetrahedron, 1986 , vol. 42, # 7 p. 2117 - 2120
反应条件
in ethanol 1 h; Reflux;
参考文献
TAIVEX THERAPEUTICS CORPORATION; HUANG, Yu-Ling; CHUANG, Shih-Hsien; LEE, Ying-Shuan Eda; HUANG, Jiann-Jyh; LAU, Johnson
Patent: WO2013/82324 A1, 2013 ;
Location in patent: Paragraph 00346 ;
