1-Fluoro-1-deoxy-α-D-glucose合成路线 （共 40 条）
反应条件
methanol; sodium methylate T=0°C; Zemplen deacetylation; pH=8.5; 2 h;
参考文献
Steinmann, Andreas; Thimm, Julian; Matwiejuk, Martin; Thiem, Joachim
Macromolecules, 2010 , vol. 43, # 8 p. 3606 - 3612
反应条件
potassium fluoride; Agrobacterium sp. β-glucosidase in water T=25°C; pH=6.0; Enzymatic reaction; Enzyme kinetics; Further Variations:Reagentsother mutant enzymes;
参考文献
Zechel; Reid; Nashiru; Mayer; Stoll; Jakeman; Warren; Withers
Journal of the American Chemical Society, 2001 , vol. 123, # 18 p. 4350 - 4351
反应条件
hydrogen sulfide in hydrogen fluoride T=-10°C; 1 h; Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Defaye; Gadelle; Pedersen
Carbohydrate Research, 1991 , vol. 217, p. 51 - 58
反应条件
hydrogen fluoride T=20°C; 0.75 h;
参考文献
Defaye, Jacques; Gadelle, Andree
Carbohydrate Research, 1982 , vol. 110, p. 217 - 228
反应条件
1: pyridine; hydrogen fluoride / 4 h / 20 °C / Sealed vial 2: methanol; sodium methylate / 2 h / 0 °C / pH 8.5 View Scheme
参考文献
Wei, Jinhua; Lv, Xun; Lue, Yang; Yang, Gangzhu; Fu, Lifeng; Yang, Liu; Wang, Jianjun; Gao, Jianhui; Cheng, Shuihong; Duan, Qian; Jin, Cheng; Li, Xuebing
European Journal of Organic Chemistry, 2013 , # 12 p. 2414 - 2419
反应条件
1: 78 percent / HF, pyridine / 4 h / Ambient temperature 2: 85 percent / NaOMe / methanol / 1 h / Ambient temperature View Scheme
参考文献
Horneman, Anne Marie; Lundt, Inge
Journal of Carbohydrate Chemistry, 1995 , vol. 14, # 1 p. 1 - 8
反应条件
Thermus nonproteolyticus HG102 E338A mutant; glycine; sodium hydroxide in aq. buffer T=45°C; pH=8.8; 48 h; Enzymatic reaction; Overall yield = 97 percent;
参考文献
European Journal of Organic Chemistry, , # 12 p. 2414 - 2419
反应条件
Thermus nonproteolyticus HG102 E338A mutant; glycine; sodium hydroxide in aq. buffer T=45°C; pH=8.8; 48 h; Enzymatic reaction; pH-valueConcentrationTemperature; Overall yield = 96 percent;
参考文献
European Journal of Organic Chemistry, , # 12 p. 2414 - 2419
反应条件
AbgGlu358Ala; ammonium bicarbonate buffer 8 h; Ambient temperature;
参考文献
Journal of the American Chemical Society, , vol. 120, # 22 p. 5583 - 5584
反应条件
1: 38 percent / AbgGlu358Ala, ammonium bicarbonate buffer / 8 h / Ambient temperature 2: 8 percent / AbgGlu358Ala, ammonium bicarbonate buffer / 8 h / Ambient temperature View Scheme
参考文献
Journal of the American Chemical Society, , vol. 120, # 22 p. 5583 - 5584
