1: With tin(IV) chloride in 1,2-dichloro-ethane T=20°C; 5 h; 2: With sodium hydrogencarbonate in 1,2-dichloro-ethane

chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane; tin(IV) chloride in acetonitrile T=24°C; 6.5 h;

3,3-dimethyldioxirane in dichloromethane T=25°C;

1: 1,2-dichloro-ethane 2: stannic chloride / 1 h View Scheme

1.1: 93 percent / NaOCH3 / methanol / 3 h / 20 °C 2.1: (OCH3)3PO; POCl3; 1,8-bis(dimethylamino)naphthalene / 0 - 4 °C 2.2: aq. triethylammonium hydrogen bicarbonate buffer / 1 h / 20 °C / pH 7.4 - 7.6 View Scheme

1.1: 93 percent / NaOCH3 / methanol / 3 h / 20 °C 2.1: (OCH3)3PO; POCl3; 1,8-bis(dimethylamino)naphthalene / 0 - 4 °C 2.2: bis(tri-n-butylammonium)pyrophosphate / dimethylformamide / 0 °C 2.3: aq. triethylammonium hydrogen bicarbonate buffer / dimethylformamide / 1 h / 20 °C / pH 7.4 - 7.6 View Scheme

sodium methylate in methanol T=20°C; 3 h;

tert.-butylhydroperoxide in acetonitrile 12 h;