反应条件
1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 1 h, 2.) a) from -78 deg C to RT, b) RT, 24 h
2: 61 percent / aq. HCl / tetrahydrofuran / 6 h / 60 °C
3: 82 percent / aq. KOH / ethanol / 3.5 h / Heating
View Scheme
参考文献
Kalgutkar, Amit S.; Kozak, Kevin R.; Crews, Brenda C.; Hochgesang Jr., G. Phillip; Marnett, Lawrence J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 24 p. 4800 - 4818
