8-氨基-3,4-二氢萘-1(2H)-酮合成路线 （共 10 条）
反应条件
hydrogenchloride in water T=90°C; 3 h;
参考文献
WO2003/99795 A1, ;
Page 74, 75 ;
WO 03/099795 A1
反应条件
trifluoroacetic acid in dichloromethane T=-50 - 20°C; 3.5 h;
参考文献
Journal of the American Chemical Society, , vol. 128, # 15 p. 4946 - 4947
反应条件
1: pyridine / 20 °C 2: KMnO4; aq. MgSO4 / acetone 3: aq. NaOH / ethanol / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 8 p. 2281 - 2284
反应条件
1: KMnO4; aq. MgSO4 / acetone 2: aq. NaOH / ethanol / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 8 p. 2281 - 2284
反应条件
hydrogenchloride; iron(II) sulfate; tin(ll) chloride
参考文献
Yakugaku Zasshi, , vol. 62, p. 236,238; dtsch. Ref. S. 57
Chem.Abstr., , p. 9869
参考文献
Nakamura
Yakugaku Zasshi, 1942 , vol. 62, p. 236,238; dtsch. Ref. S. 57
Chem.Abstr., 1950 , p. 9869
反应条件
1: With hydrogen bromide; sodium nitrite in ethanol; water T=0°C; 0.25 h; 2: With hydrogen bromide; copper(I) bromide in ethanol; water T=95°C; Sandmeyer-type reaction; 0.25 h;
参考文献
Chen, Chien-Tien; Chen, Chien-Hsiang; Ong, Tiow-Gan
Journal of the American Chemical Society, 2013 , vol. 135, # 14 p. 5294 - 5297
反应条件
tert.-butylnitrite; copper dichloride in acetonitrile T=65°C; 0.166667 h;
参考文献
Nguyen, Phong; Corpuz, Evelyn; Heidelbaugh, Todd M.; Chow, Ken; Garst, Michael E.
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10195 - 10198
反应条件
1: With NOBF4 in acetone T=-20°C; 1.25 h; 2: in toluene Schiemann reaction; 0.25 h; Heating;
参考文献
Nguyen, Phong; Corpuz, Evelyn; Heidelbaugh, Todd M.; Chow, Ken; Garst, Michael E.
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10195 - 10198
反应条件
sodium hydroxide; BF3.OEt2 in dichloromethane; chloroform; ethyl acetate
参考文献
Heidelbaugh, Todd M.; Chow, Ken; Nguyen, Phong; Gil, Daniel; Donello, John E.
Patent: US2005/75366 A1, 2005 ;
US 20050075366 A1
