2-氨基-4-(对甲苯基)噻唑合成路线 （共 21 条）
反应条件
in ethanol 1 h; Reflux;
参考文献
TAIVEX THERAPEUTICS CORPORATION; HUANG, Yu-Ling; CHUANG, Shih-Hsien; LEE, Ying-Shuan Eda; HUANG, Jiann-Jyh; LAU, Johnson
Patent: WO2013/82324 A1, 2013 ;
Location in patent: Paragraph 00265 ;
反应条件
iodine T=130 - 150°C; 0.166667 h; Neat (no solvent)Microwave irradiation;
参考文献
Caceres-Castillo, David; Carballo, Ruben M.; Tzec-Interian, Jorge A.; Mena-Rejon, Gonzalo J.
Tetrahedron Letters, 2012 , vol. 53, # 30 p. 3934 - 3936
反应条件
sulfuryl dichloride; thiourea in water; acetone
参考文献
SAWAI PHARMACEUTICAL CO., LTD.
Patent: EP321115 B1, 1991 ;
反应条件
iodine; copper(II) oxide in ethanol T=78°C;
参考文献
Tetrahedron, , vol. 68, # 1 p. 173 - 178
反应条件
copper(II) bis(trifluoromethanesulfonate) in 1,2-dichloro-ethane T=80°C; 2 h;
参考文献
Yadav; Reddy, B.V. Subba; Rao, Y. Gopala; Narsaiah
Tetrahedron Letters, 2008 , vol. 49, # 15 p. 2381 - 2383
参考文献
Tetrahedron Letters, , vol. 53, # 30 p. 3835 - 3838
反应条件
β-cyclodextrin in water; acetone T=20°C; 1.5 h;
参考文献
Kumar, V. Pavan; Narender; Sridhar; Nageswar; Rao, K. Rama
Synthetic Communications, 2007 , vol. 37, # 24 p. 4331 - 4336
反应条件
1-methyl-1H-imidazole in water; isopropyl alcohol T=20°C; 1.2 h;
参考文献
Meshram; Thakur, Pramod B.; Madhu Babu; Bangade, Vikas M.
Tetrahedron Letters, 2012 , vol. 53, # 39 p. 5265 - 5269
反应条件
in methanol 7 h; Ambient temperature;
参考文献
De Kimpe, Norbert; De Cock, Wim; Keppens, Marian; De Smaele, Dirk; Meszaros, Andrea
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 4 p. 1179 - 1183
反应条件
1: N-bromosuccinmide; water; β-cyclodextrin / 0.17 h / 70 °C 2: water / 70 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 53, # 30 p. 3835 - 3838
