Z-ALA-PRO-OH合成路线 （共 17 条）
反应条件
1: 93 percent / TFA / CH2Cl2
2: 70 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; HOBt / CH2Cl2 / 0 - 20 °C
3: 66 percent / tyrosinase; phosphate buffer; O2 / H2O; acetonitrile / 6 h / 20 °C / pH 7.0
View Scheme
参考文献
Voelkert, Martin; Koul, Surrinder; Mueller, Gernot H.; Lehnig, Manfred; Waldmann, Herbert
Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 6902 - 6910
反应条件
1: 92 percent / piperidine
2: 70 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; HOBt / CH2Cl2 / 0 - 20 °C
3: 66 percent / tyrosinase; phosphate buffer; O2 / H2O; acetonitrile / 6 h / 20 °C / pH 7.0
View Scheme
参考文献
Voelkert, Martin; Koul, Surrinder; Mueller, Gernot H.; Lehnig, Manfred; Waldmann, Herbert
Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 6902 - 6910
反应条件
1: 83 percent / ethyl acetate; dimethylformamide / 2 h / -10 - 20 °C
2: 85 percent / NaOH; HCl / methanol; CH2Cl2 / 3 h
View Scheme
参考文献
Gudasheva; Vasilevich; Ostrovskaya; Trofimov; Voronina; Skoldinov; Rozantsev
Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 9 p. 562 - 567
反应条件
1-hydroxy-pyrrolidine-2,5-dione; sodium hydrogencarbonate; dicyclohexyl-carbodiimide
1) DME, 0 deg C, 12 h, 2) DME, H2O, RT, 3h; Multistep reaction;
参考文献
Baldwin, Jack E.; Brown, David; Scudder, Paul H.; Wood, Mark E.
Tetrahedron Letters, 1995 , vol. 36, # 12 p. 2105 - 2108
反应条件
formic acid
24 h; Ambient temperature; Yield given;
参考文献
Paulsen, Hans; Adermann, Knut
Liebigs Annalen der Chemie, 1989 , p. 751 - 770
反应条件
1: hydrogene / Pd-C / aq. NaOH
2: dioxane / 24 h
3: 72 percent / N-ethylmorpholine, isobutyl chloroformate / tetrahydrofuran / -15 - 20 °C
4: 6.2N HCl / dioxane / 1 h
View Scheme
参考文献
Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
反应条件
1: hydrogene / Pd-C / aq. NaOH
2: dioxane / 24 h
View Scheme
参考文献
Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
