4-氨基四氢-2H-噻喃 1,1-二氧化物合成路线 (共 7 条)
反应条件
hydrogen; nickel in methanol T=20°C; 3 h;
参考文献
Arete Therapeutics, Inc.
Patent: US2009/82423 A1, 2009 ;
Location in patent: Page/Page column 24 ;
US 20090082423 A1
反应条件
palladium(II) hydroxide/carbon in ethanol P=2585.81 Torr; 15 h;
参考文献
Goldstein, David Michael; Hawley, Ronald Charles; Lui, Alfred Sui-Ting; Sjogren, Eric Brian
Patent: US2003/232847 A1, 2003 ;
Location in patent: Page 16 ;
US 20030232847 A1
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 0.5 h;
参考文献
WO2008/33562 A2, ;
Page/Page column 49 ;
反应条件
1: hydroxylamine 2: Raney nickel; ethanol / 40 °C / 58840.6 Torr / Hydrogenation View Scheme
参考文献
Journal of the American Chemical Society, , vol. 77, p. 3866,3867
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / |Reflux 2: triethylamine / dichloromethane / 2 h 3: 3-chloro-benzenecarboperoxoic acid; triethylamine / dichloromethane 4: trifluoroacetic acid / dichloromethane / 2 h View Scheme
反应条件
1: triethylamine / dichloromethane / 2 h 2: 3-chloro-benzenecarboperoxoic acid; triethylamine / dichloromethane 3: trifluoroacetic acid / dichloromethane / 2 h View Scheme
反应条件
1: sodium acetate; hydroxylamine hydrochloride / ethanol 2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / |Reflux 3: triethylamine / dichloromethane / 2 h 4: 3-chloro-benzenecarboperoxoic acid; triethylamine / dichloromethane 5: trifluoroacetic acid / dichloromethane / 2 h View Scheme