5-溴烟酸乙酯合成路线

20986-40-75-溴烟酸乙酯

参考文献

Cosford; Bleicher; Herbaut; McCallum; Vernier J.-; Dawson; Whitten; Adams; Chavez-Noriega; Correa; Crona; Mahaffy; Menzaghi; Rao; Reid; Sacaan; Santori; Stauderman; Whelan; et
Journal of Medicinal Chemistry, 1996 , vol. 39, # 17 p. 3235 - 3237

20986-40-75-溴烟酸乙酯

112193-41-65-溴吡啶-3-甲酰肼

参考文献

Kuznetsova, E. A.; Voronina, T. A.; Khromova, I. V.; Garibova, T. L.; Tosina, E. K.; et al.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 12 p. 943 - 949
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 12 p. 1425 - 1431

20986-40-75-溴烟酸乙酯

113118-81-35-溴吡啶-3-甲醛

参考文献

Journal of Medicinal Chemistry, , vol. 38, # 10 p. 1608 - 1628

20986-40-75-溴烟酸乙酯+

1679-18-14-氯苯硼酸

1258269-08-75-(4-氯苯基)烟酸乙酯

参考文献

Ranasinghe, Nadeesha; Jones, Graham B.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1740 - 1742

20986-40-75-溴烟酸乙酯+

536-74-3苯乙炔

175203-65-35-(2-苯基-1-乙炔)烟酸乙酯

参考文献

WO2008/61236 A2, ;

Page/Page column 33 ;

20986-40-75-溴烟酸乙酯

179120-92-45-乙炔基尼古丁

参考文献

Cosford; Bleicher; Herbaut; McCallum; Vernier J.-; Dawson; Whitten; Adams; Chavez-Noriega; Correa; Crona; Mahaffy; Menzaghi; Rao; Reid; Sacaan; Santori; Stauderman; Whelan; et
Journal of Medicinal Chemistry, 1996 , vol. 39, # 17 p. 3235 - 3237

20986-40-75-溴烟酸乙酯

71719-09-0

参考文献

Cosford; Bleicher; Herbaut; McCallum; Vernier J.-; Dawson; Whitten; Adams; Chavez-Noriega; Correa; Crona; Mahaffy; Menzaghi; Rao; Reid; Sacaan; Santori; Stauderman; Whelan; et
Journal of Medicinal Chemistry, 1996 , vol. 39, # 17 p. 3235 - 3237

20986-40-75-溴烟酸乙酯

83023-56-7(2R)-5-溴-3-(2-吡咯烷)吡啶

参考文献

Jacob III
Journal of Organic Chemistry, 1982 , vol. 47, # 21 p. 4165 - 4167

20986-40-75-溴烟酸乙酯

855301-00-75-(2-氯苯基)-3-吡啶羧醛

参考文献

Pfefferkorn, Jeffrey A.; Greene, Meredith L.; Nugent, Richard A.; Gross, Rebecca J.; Mitchell, Mark A.; Finzel, Barry C.; Harris, Melissa S.; Wells, Peter A.; Shelly, John A.; Anstadt, Robert A.; Kilkuskie, Robert E.; Kopta, Laurice A.; Schwende, Francis J.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2481 - 2486

20986-40-75-溴烟酸乙酯+

1066-54-2三甲基乙炔基硅

866683-43-4

参考文献

ELI LILLY AND COMPANY
Patent: WO2005/94822 A1, 2005 ;
Location in patent: Page/Page column 33 ;
WO 2005/094822 A1