6-氯-4-甲基-2-氰基吡啶合成路线 （共 5 条）
反应条件
1: 2-chloro-4-methyl-pyridine 1-oxide With dimethyl sulfate 2: sodium cyanide in water T=-15 - -7°C; Inert atmosphere;
参考文献
MERCK SHARP and DOHME CORP.; WOOD, Harold, B.; ADAMS, Alan, D.; SZEWCZYK, Jason, W.; ZHANG, Yong; YANG, Meng
Patent: WO2011/19538 A1, 2011 ;
Location in patent: Page/Page column 123-124 ;
WO 2011/019538 A1
反应条件
dimethyl sulfate in water
参考文献
Kureha Kagaku Kabushiki Kaisha
Patent: US6200933 B1, 2001 ;
反应条件
sodium chloride in hexane; ethyl acetate; N,N-dimethyl-formamide
参考文献
American Cyanamid Company
Patent: US5707932 A1, 1998 ;
反应条件
1.1: dihydrogen peroxide; acetic acid / water / 18 h / 65 °C / Inert atmosphere 2.1: dimethyl sulfate 2.2: -15 - -7 °C / Inert atmosphere View Scheme
参考文献
MERCK SHARP and DOHME CORP.; WOOD, Harold, B.; ADAMS, Alan, D.; SZEWCZYK, Jason, W.; ZHANG, Yong; YANG, Meng
Patent: WO2011/19538 A1, 2011 ;
WO 2011/019538 A1
反应条件
in hydrogenchloride; water
参考文献
Kureha Kagaku Kogyo K.K.
Patent: US6610853 B1, 2003 ;
