2-(4-氨基-3-溴苯基)乙酸甲酯合成路线 （共 5 条）
反应条件
acetic acid in methanol; water
参考文献
Daiichi Pharmaceutical Co., LTD.
Patent: US2003/78249 A1, 2003 ;
反应条件
sodium acetate; iron; acetic acid in methanol; water T=110°C; 1 h;
参考文献
Chiba, Jun; Iimura, Shin; Yoneda, Yoshiyuki; Watanabe, Toshiyuki; Muro, Fumito; Tsubokawa, Masao; Iigou, Yutaka; Satoh, Atsushi; Takayama, Gensuke; Yokoyama, Mika; Takashi, Tohru; Nakayama, Atsushi; Machinaga, Nobuo
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 4 p. 1679 - 1693
反应条件
Oxonereg;; sodium bromide in water; acetone T=20°C; 0.05 h;
参考文献
Kang, Dong Wook; Kim, Yong Soo; Lim, Kwang Su; Kim, Myeong Seop; Pearce, Larry V.; Pavlyukovets, Vladimir A.; Tao, Andy K.; Lang-Kuhs, Krystle A.; Blumberg, Peter M.; Lee, Jeewoo
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 22 p. 8092 - 8105
反应条件
1: 99 percent / H2SO4 / 1,2-dichloro-ethane / 2 h / 80 °C 2: 29 percent / H2SO4; HNO3 / 4 h / 0 - 20 °C 3: 69 percent / iron; NaOAc*3H2O; acetic acid / methanol; H2O / 1 h / 110 °C View Scheme
参考文献
Chiba, Jun; Iimura, Shin; Yoneda, Yoshiyuki; Watanabe, Toshiyuki; Muro, Fumito; Tsubokawa, Masao; Iigou, Yutaka; Satoh, Atsushi; Takayama, Gensuke; Yokoyama, Mika; Takashi, Tohru; Nakayama, Atsushi; Machinaga, Nobuo
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 4 p. 1679 - 1693
反应条件
1: 29 percent / H2SO4; HNO3 / 4 h / 0 - 20 °C 2: 69 percent / iron; NaOAc*3H2O; acetic acid / methanol; H2O / 1 h / 110 °C View Scheme
参考文献
Chiba, Jun; Iimura, Shin; Yoneda, Yoshiyuki; Watanabe, Toshiyuki; Muro, Fumito; Tsubokawa, Masao; Iigou, Yutaka; Satoh, Atsushi; Takayama, Gensuke; Yokoyama, Mika; Takashi, Tohru; Nakayama, Atsushi; Machinaga, Nobuo
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 4 p. 1679 - 1693
