(3α,5β,7α,12α)-3,7,12-三(甲酰氧基)胆烷-24-酸合成路线 （共 3 条）
→
1061-64-9(2R,3R,6R)-2,3-二羟基-6-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-羟基-10,13-二甲基十六碳氢-1H-环戊二烯并[a]菲-17-基]庚酸
反应条件
1: SOCl2 / benzene / 2 h / Ambient temperature 2: tetramethylammonium hydridoirontetracarbonyl / CH2Cl2 / 4 h / Ambient temperature 3: 1) Zn, I2, Cu, 2) 10percent KOH / 1) toluene, reflux, 5 h, 2) ethanol, 3 h View Scheme
参考文献
Batta, A. K.; Tint, G. S.; Dayal, B.; Shefer, S.; Salen, G.
Steroids, 1982 , vol. 39, # 6 p. 693 - 702
→
18866-87-0(3R,5S,7R,8R,9S,10S,12S,13R,14S)-17-[(2R)-6-羟基-6-甲基庚烷-2-基]-10,13-二甲基-2,3,4,5,6,7,8,9,11,12,14,15,16,17-十四氢-1H-环戊二烯并[a]菲-3,7,12-三醇
反应条件
1: 1.) (COCl)2 / 1.) benzene, RT, 2 h, 2.) benzene, RT, overnight 2: aq. AgNO3 / methanol / 4 h / Heating 3: methanesulfonic acid / 0.01 h / Irradiation 4: diethyl ether; benzene / Ambient temperature View Scheme
参考文献
Dayal, B.; Bagan, E.; Speck, J.; Salen, G.
Steroids, 1980 , vol. 35, # 4 p. 439 - 444
反应条件
1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / -78 - 20 °C 2: sulfur trioxide pyridine complex / dichloromethane / 24 h / 20 °C 3: sodium hydroxide / methanol; water / 12 h / 50 °C View Scheme
参考文献
Steroids, , vol. 76, # 3 p. 291 - 300
