2-乙酰基-4-甲基-4-戊烯酸乙酯合成路线 （共 16 条）
反应条件
1: H2O 2: aq. sodium hydroxide / Heating 3: 3 percent / pentane; methylcyclohexane / 15 °C / Irradiation View Scheme
参考文献
Leigh, William J.; Srinivasan, R.
Journal of the American Chemical Society, 1982 , vol. 104, # 16 p. 4424 - 4429
反应条件
sodium ethanolate; sodium in ethanol
参考文献
Commissariat a l'Energie Atomique
Patent: US5006663 A1, 1991 ;
反应条件
sodium hydroxide 2 h; Heating;
参考文献
Rosini, Goffredo; Marotta, Emanuela; Petrini, Marino; Ballini, Roberto
Tetrahedron, 1985 , vol. 41, # 20 p. 4633 - 4638
反应条件
potassium carbonate in acetonitrile
T=20°C; 62 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/62370 A2, 2007 ;
Location in patent: Page/Page column 40 ;
反应条件
sodium ethanolate in N2
参考文献
Union Camp Corporation
Patent: US5292719 A1, 1994 ;
反应条件
isopropylmagnesium chloride; sodium hydride; Cl2Ni(1,2-bis(diphenylphosphino)ethane) in tetrahydrofuran
T=160°C; 72 h; other temp./react. time; Product distribution;
参考文献
Cuvigny, Therese; Julia, Marc
Journal of Organometallic Chemistry, 1986 , vol. 317, p. 383 - 408
反应条件
pyrrolidine; [PtCl2(η2:η2-cycloocta-1,5-diene)]; acetic acid; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in N,N-dimethyl-formamide
T=80°C; 5 h; Inert atmosphereSchlenk techniqueMicrowave irradiation; Temperature; regioselective reaction;
参考文献
Shibuya, Ryozo; Lin, Lu; Nakahara, Yasuhito; Mashima, Kazushi; Ohshima, Takashi
Angewandte Chemie - International Edition, 2014 , vol. 53, # 17 p. 4377 - 4381
Angew. Chem., 2014 , vol. 126, # 17 p. 4466 - 4470,5
反应条件
titanium tetrachloride in dichloromethane
T=-78°C; 2 h;
参考文献
Molander, Gary A.; Andrews, Steven W.
Tetrahedron Letters, 1986 , vol. 27, # 27 p. 3115 - 3118
反应条件
1: 1.) NaH
2: TiCl4 / CH2Cl2 / 2 h / -78 °C
View Scheme
参考文献
Molander, Gary A.; Andrews, Steven W.
Tetrahedron Letters, 1986 , vol. 27, # 27 p. 3115 - 3118
反应条件
potassium hydroxide; acetaldehyde dipropyl acetal
参考文献
Weizmann et al.
Journal of Organic Chemistry, 1950 , vol. 15, p. 918,920
