反应条件
1: 1.) dibutyltin oxide, 2.) Et3N / 1.) MeOH, reflux, 2 h, 2.) 15 min
2: 94 percent / lithium triethylborohydride / dimethylsulfoxide; tetrahydrofuran
3: 47 percent / pyridine / 72 h
4: 1.) pyridine, 2.) aq. acetic acid / 1.) 2 d, 2.) 80 deg C, 30 min
5: 85 percent / LiN3 / dimethylformamide / 2 h / 100 °C
View Scheme
参考文献
Robins; Wood; Dalley; Herdewijn; Balzarini; De Clercq
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1763 - 1768
