2-苯基-1,3-噻唑-4-甲醛合成路线 （共 16 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-78 - -20°C; 1 h;
参考文献
GTX, INC.; UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION; DALTON, James, T.; MILLER, Duane, D.; AHN, Sunjoo; CHEN, Jianjun; DUKE, Charles; LI, Chien-ming; LI, Wei; LU, Yan; WANG, Zhao
Patent: WO2011/109059 A1, 2011 ;
Location in patent: Paragraph 0036; 00292 ;
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine in dichloromethane T=-78 - 0°C; Swern oxidation;
参考文献
Millan, David S.; Prager, Rolf H.; Brand, Catherine; Hart, Prue H.
Tetrahedron, 2000 , vol. 56, # 5 p. 811 - 816
反应条件
sodium hydrogencarbonate; dimethyl sulfoxide T=130°C; Oxidation; 1 h;
参考文献
Einsiedel, Juergen; Thomas, Christoph; Huebner, Harald; Gmeiner, Peter
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 17 p. 2041 - 2044
反应条件
1: acetone / 16 h / 20 °C 2: conc. H2SO4 / 0.75 h / 20 °C 3: 60 percent / NaHCO3; DMSO / 1 h / 130 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 17 p. 2041 - 2044
反应条件
water in ethanol T=80°C; 3 h;
参考文献
Chemische Berichte, , vol. 101, # 11 p. 3872 - 3882
反应条件
1: pyridine; hydrogen sulfide; triethylamine 2: toluene / 2 h / Reflux 3: sulfuric acid; water / Reflux 4: manganese(IV) oxide / chloroform / 12 h / 20 °C View Scheme
参考文献
Archiv der Pharmazie, , vol. 343, # 7 p. 411 - 416
反应条件
1: H2SO4 2: H2O / ethanol / 3 h / 80 °C View Scheme
参考文献
Chemische Berichte, , vol. 101, # 11 p. 3872 - 3882
反应条件
1: trichloromonobromomethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -78 - -20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 13 p. 4678 - 4693
反应条件
1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 20 °C 1.2: 20 °C 2.1: trichloromonobromomethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -78 - -20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 13 p. 4678 - 4693
反应条件
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 20 °C 2.1: trichloromonobromomethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -78 - -20 °C / Inert atmosphere 3.2: Cooling with ice View Scheme
