7,8-二甲氧基-1,3,4,5-四氢苯并氮杂卓-2-酮合成路线 （共 23 条）
反应条件
palladium/charcoal in dichloromethane; acetic acid
反应条件
1: With trifluoroacetic acid in dichloromethane T=0 - 5°C; 5 h; Inert atmosphere; 2: With sodium hydrogencarbonate in dichloromethane
参考文献
EP2097383 B1, ;
Page/Page column 8-9 ;
反应条件
chloro-trimethyl-silane; sodium iodide in acetonitrile T=20°C; 24 h;
参考文献
Pauvert, Mickael; Collet, Sylvain; Guingant, Andre
Tetrahedron Letters, 2003 , vol. 44, # 22 p. 4203 - 4206
参考文献
Ishibashi, Hiroyuki; Sato, Kazumi; Ikeda, Masazumi; Maeda, Hiroshi; Akai, Shuji; Tamura, Yasumitsu
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 605 - 610
反应条件
sodium azide; methanesulfonic acid T=20°C; Schmidt reaction; 18 h;
参考文献
Dalence-Guzman, Maria F.; Berglund, Magnus; Skogvall, Staffan; Sterner, Olov
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 5 p. 2499 - 2512
反应条件
1: pyridine / benzene / 0 deg C to room temp. overnight 2: 84 percent / NaIO4 / methanol; H2O / 0 deg C to room temp. overnight 3: 8 percent / toluene-p-sulphonic acid / 1,2-dichloro-ethane / 0.17 h / Heating 4: 84 percent / Raney nickel W-2 / ethanol / 1 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 605 - 610
反应条件
1: 84 percent / NaIO4 / methanol; H2O / 0 deg C to room temp. overnight 2: 8 percent / toluene-p-sulphonic acid / 1,2-dichloro-ethane / 0.17 h / Heating 3: 84 percent / Raney nickel W-2 / ethanol / 1 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 605 - 610
反应条件
1: 8 percent / toluene-p-sulphonic acid / 1,2-dichloro-ethane / 0.17 h / Heating 2: 84 percent / Raney nickel W-2 / ethanol / 1 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 605 - 610
反应条件
1: 89 percent / toluene / 2 h / Heating 2: 76 percent / aq. KOH / acetonitrile; H2O / 3 h / 20 °C 3: 71 percent / aq. silver nitrate / acetonitrile; H2O / 16 h / 20 °C 4: 95 percent / Na; liq. NH3 / tetrahydrofuran / 0.5 h / -78 °C 5: 98 percent / Me3SiCl; NaI / acetonitrile / 24 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 22 p. 4203 - 4206
反应条件
1: 76 percent / aq. KOH / acetonitrile; H2O / 3 h / 20 °C 2: 71 percent / aq. silver nitrate / acetonitrile; H2O / 16 h / 20 °C 3: 95 percent / Na; liq. NH3 / tetrahydrofuran / 0.5 h / -78 °C 4: 98 percent / Me3SiCl; NaI / acetonitrile / 24 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 22 p. 4203 - 4206
