sodium hydroxide in acetone a.) 0 deg C, 1 h, b) RT, 3 h;

1: 85 percent / Et3N, 1-hydroxybenzotriazole, N,N-dicyclohexylcarbodiimide / CHCl3; tetrahydrofuran / Ambient temperature 2: 95 percent / 1N NaOH / acetone / a.) 0 deg C, 1 h, b) RT, 3 h View Scheme

1: 85 percent / Et3N, 1-hydroxybenzotriazole, N,N-dicyclohexylcarbodiimide / CHCl3; tetrahydrofuran / Ambient temperature 2: 95 percent / 1N NaOH / acetone / a.) 0 deg C, 1 h, b) RT, 3 h View Scheme