4-氨基-5-氯-2-甲氧基苯甲酸甲酯合成路线 （共 12 条）
反应条件
methanol; thionyl chloride 16 h; Reflux;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: US2010/168094 A1, 2010 ;
Location in patent: Page/Page column 66 ;
US 20100168094 A1
反应条件
thionyl chloride T=80°C; 5 h;
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
Location in patent: Page/Page column 59 ;
US 20120277224 A1
反应条件
in methanol; hexane; toluene T=0 - 20°C; 16 h;
参考文献
US2005/113417 A1, ;
Page/Page column 46 ;
反应条件
in methanol; hexane; toluene T=20°C; 16 h;
参考文献
WO2006/23457 A1, ;
Page/Page column 76 ;
WO 2006/023457 A1
反应条件
potassium carbonate in dimethyl sulfoxide 4 h; Heating;
参考文献
Ohmori; Maeno; Hidaka; Nakato; Matsumoto; Tada; Hattori; Sakamoto; Tsukamoto; Usuda; Mase
Journal of medicinal chemistry, 1996 , vol. 39, # 14 p. 2764 - 2772
反应条件
N-chloro-succinimide in acetonitrile Chlorination; 1 h; Heating;
参考文献
Ehrenkaufer, Richard L.; Scripko, James G.; Hoffman, Patricia L.
Organic Preparations and Procedures International, 1992 , vol. 24, # 1 p. 64 - 66
反应条件
acetic acid T=50°C; 5 h;
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
Location in patent: Page/Page column 59 ;
US 20120277224 A1
反应条件
acetic acid in acetic anhydride
参考文献
Rorer Pharmaceutical Corporation
Patent: US4863921 A1, 1989 ;
反应条件
sodium hydroxide; boron tribromide in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane
参考文献
Rorer Pharmaceutical Corp.
Patent: US4920219 A1, 1990 ;
US 4920219 A
反应条件
potassium acetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; bis(dibenzylideneacetone)-palladium(0) in N,N-dimethyl acetamide T=120°C;
参考文献
Jia, Yanxing; Zhu, Jieping
Journal of Organic Chemistry, 2006 , vol. 71, # 20 p. 7826 - 7834
