1: 4-DMAP, Et3N / CH2Cl2 2: RuO4, NaIO4 / CCl4; acetonitrile; H2O 3: K2CO3 / methanol View Scheme

sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; Dess-Martin periodane in water; tert-butyl alcohol

<b>Multi-step reaction with 2 steps<br /> </b>1: Et₃N, 4-DMAP / tetrahydrofuran<br />2: Cs₂CO₃ / methanol<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: 87 percent / RuO₄, NaIO₄ / CCl₄; acetonitrile; H₂O<br />2: 62 percent / DPPA, Et₃N / toluene / Heating<br />3: 98 percent / BF₃*OEt₂ / tetrahydrofuran<br />4: Et₃N, 4-DMAP / tetrahydrofuran<br />5: Cs₂CO₃ / methanol<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 62 percent / DPPA, Et₃N / toluene / Heating<br />2: 98 percent / BF₃*OEt₂ / tetrahydrofuran<br />3: Et₃N, 4-DMAP / tetrahydrofuran<br />4: Cs₂CO₃ / methanol<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 98 percent / BF₃*OEt₂ / tetrahydrofuran<br />2: Et₃N, 4-DMAP / tetrahydrofuran<br />3: Cs₂CO₃ / methanol<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: Et₃N, 4-DMAP / tetrahydrofuran<br />2: Cs₂CO₃ / methanol<br /> <br /> &nbsp;