1: 98 percent / BF3*OEt2 / tetrahydrofuran 2: Et3N, 4-DMAP / tetrahydrofuran 3: Cs2CO3 / methanol 4: 1.) Dess-Martin reagent, NaClO2, 2-Me-2-butene, NaH2Po4 / 2-methyl-propan-2-ol; H2O View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '2804567', constants.ctx, '0')">diphenyl-phosphinic acid</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '635760', constants.ctx, '0')">toluene</a> <br />&nbsp;Heating;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 87 percent / RuO₄, NaIO₄ / CCl₄; acetonitrile; H₂O<br />2: 62 percent / DPPA, Et₃N / toluene / Heating<br /> <br /> &nbsp;