1-苄氧基-2-甲基-3-硝基苯合成路线 （共 18 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 3 h;
参考文献
Seike, Hisayuki; Matsugi, Takeshi; Shimazaki, Atsushi
Patent: US2009/12123 A1, 2009 ;
Location in patent: Page/Page column 9-10 ;
反应条件
1: 3-hydroxy-2-methylnitrobenzene With potassium carbonate in N,N-dimethyl-formamide 2: benzyl bromide in N,N-dimethyl-formamide T=20°C; 3 h;
参考文献
Ube Industries, Ltd.; SANTEN PHARMACEUTICAL CO., LTD.
Patent: EP1679308 A1, 2006 ;
Location in patent: Page/Page column 42 ;
EP 1679308 A1
反应条件
sodium ethanolate in ethanol 8 h; Heating;
参考文献
Brenneisen; Borner; Peter-Oesch; Schlunegger
Archiv der Pharmazie, 1988 , vol. 321, # 8 p. 487 - 489
反应条件
1: (i) NaNO2, aq. H2SO4, (ii) CuSO4 2: K2CO3 View Scheme
参考文献
Tetrahedron, , vol. 24, p. 6093 - 6109
参考文献
Helvetica Chimica Acta, , vol. 38, p. 1452,1469
反应条件
1: 74 percent / 2.5 h / 120 °C / 10 - 20 Torr 2: 1.) Et2O, -10 deg C, 1 h 3: 46 percent / LiAlH4 / dioxane / 17 h / Heating 4: 95 percent / H2 / 5percent Pd/Al2O3 / methanol / 5 h 5: 1.) sodium tert-pentanoxide / benzene / 1.) 2 h, 2.) 12 h 6: H2 / 5percent Pd/Al2O3 / methanol / 4 h View Scheme
参考文献
Brenneisen; Borner; Peter-Oesch; Schlunegger
Archiv der Pharmazie, 1988 , vol. 321, # 8 p. 487 - 489
反应条件
1.1: hydrogen; 3 platinum on carbon / ethanol / 21.5 h / 258.58 - 2585.81 Torr 2.1: potassium acetate; acetic anhydride / toluene / 3.5 h 2.2: 18 h / 80 °C 2.3: 4 h / 40 °C View Scheme
参考文献
Saenz, James; Mitchell, Mark; Bahmanyar, Sami; Stankovic, Nebojsa; Perry, Michael; Craig-Woods, Bridgette; Kline, Billie; Yu, Shu; Albizati, Kim
Organic Process Research and Development, 2007 , vol. 11, # 1 p. 30 - 38
反应条件
1: potassium ethylate; diethyl ether; toluene / Behandeln des Reaktionsprodukts in wss. NaOH mit Na2S2O4 2: quinaldine; copper-powder / 245 - 250 °C 3: acetic acid; ethanol 4: CH3I / Erwaermen des Reaktionsprodukts mit NaCN in H2O View Scheme
参考文献
Stoll et al.
Helvetica Chimica Acta, 1955 , vol. 38, p. 1452,1469
反应条件
1: potassium ethylate; diethyl ether; toluene / Behandeln des Reaktionsprodukts in wss. NaOH mit Na2S2O4 2: quinaldine; copper-powder / 245 - 250 °C 3: acetic acid; ethanol View Scheme
参考文献
Helvetica Chimica Acta, , vol. 38, p. 1452,1469
反应条件
hydrogenchloride; hydrazine hydrate; nickel monoaluminide in tetrahydrofuran; N-methyl-acetamide; methanol; ethanol; water
参考文献
Neurogen Corporation
Patent: US5750702 A1, 1998 ;
US 5750702 A
