4-甲氧基-2-硝基苯乙酸合成路线 （共 9 条）
反应条件
iron; acetic acid T=116°C; 1.66667 h;
参考文献
SUGEN, Inc.
Patent: US2004/186160 A1, 2004 ;
Location in patent: Page/Page column 24 ;
US 20040186160 A1
反应条件
1: With sodium hydroxide; ethanol; water
T=90°C; 1 h;
2: With hydrogenchloride; water
T=85°C; 1 h;
参考文献
LABORATOIRES SERONO SA
Patent: WO2008/101979 A1, 2008 ;
Location in patent: Page/Page column 72-73 ;
反应条件
sulfuric acid in water
0.333333 h; Heating;
参考文献
Loewe, Werner; Witzel, Sonja; Tappmeyer, Silvia; Albuschat, Rica
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 3 p. 317 - 326
反应条件
1: 22 percent / sodium hydride; cesium fluoride / various solvent(s); dimethylformamide / 24 h / 70 °C
2: 76 percent / conc. sulfuric acid / H2O / 0.33 h / Heating
View Scheme
参考文献
Loewe, Werner; Witzel, Sonja; Tappmeyer, Silvia; Albuschat, Rica
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 3 p. 317 - 326
反应条件
sodium hydroxide; dihydrogen peroxide
参考文献
Kermack; Perkin; Robinson
Journal of the Chemical Society, 1921 , vol. 119, p. 1612
Journal of the Chemical Society, 1922 , vol. 121, p. 1872
反应条件
1: sodium methylate
2: sodium ethylate / 35 - 40 °C / Zersetzen des Reaktionsprodukts mit Salzsaeure
3: hydrogen peroxide; NaOH-solution
View Scheme
参考文献
Kermack; Perkin; Robinson
Journal of the Chemical Society, 1921 , vol. 119, p. 1612
Journal of the Chemical Society, 1922 , vol. 121, p. 1872
反应条件
1: sodium ethylate / 35 - 40 °C / Zersetzen des Reaktionsprodukts mit Salzsaeure
2: hydrogen peroxide; NaOH-solution
View Scheme
参考文献
Kermack; Perkin; Robinson
Journal of the Chemical Society, 1921 , vol. 119, p. 1612
Journal of the Chemical Society, 1922 , vol. 121, p. 1872
反应条件
(i) KOEt, Et2O, (ii) H2O2; Multistep reaction;
参考文献
Beckett,A.H. et al.
Tetrahedron, 1968 , vol. 24, p. 6093 - 6109
参考文献
Kermack; Perkin; Robinson
Journal of the Chemical Society, 1921 , vol. 119, p. 1612
Journal of the Chemical Society, 1922 , vol. 121, p. 1872
