(5-甲氧基-2-硝基-苯基)-乙酸合成路线 （共 8 条）
反应条件
1: With sodium ethanolate in diethyl ether; ethanol T=20°C; 3 h; 2: With sodium hydroxide in water T=20°C; pH=9; 1 h; Further stages.;
参考文献
Journal of Organic Chemistry, , vol. 66, # 25 p. 8447 - 8453
反应条件
1: NaOMe / methanol 2: (i) KOEt, Et2O, (ii) H2O2 View Scheme
参考文献
Tetrahedron, , vol. 24, p. 6093 - 6109
反应条件
hydrogenchloride; water 3 h; Reflux;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 18, # 4 p. 1482 - 1496
反应条件
sulfuric acid; nitric acid
参考文献
Archiv der Pharmazie, , vol. 321, # 5 p. 265 - 272
反应条件
sodium hydroxide; dihydrogen peroxide
参考文献
Journal of the Chemical Society, , vol. 125, p. 313
反应条件
amberlyst-15 2 h; Heating;
参考文献
Cravotto; Giovenzana; Pilati; Sisti; Palmisano
Journal of Organic Chemistry, 2001 , vol. 66, # 25 p. 8447 - 8453
反应条件
1: SOCl2 / toluene; dimethylformamide / 1) r.t., overnight 2) 50 deg C 2: 1) NaH / 1) THF 2) toluene, DMF, overnight 3: 75 percent / NH4OH / methanol / 0.75 h / Ambient temperature 4: 90 percent / ammonium formate / 10percent Pd/C / methanol / 0.75 h / Ambient temperature View Scheme
参考文献
Modi, Sandeep P.; McComb, Todd; Zayed, Abdel-Hadi; Oglesby, R. Christopher; Archer, Sydney
Tetrahedron, 1990 , vol. 46, # 16 p. 5555 - 5562
反应条件
5 Pd(II)/C(eggshell); hydrogen; acetic acid T=20°C; 2 h;
参考文献
Mologni, Luca; Rostagno, Roberta; Brussolo, Stefania; Knowles, Phillip P.; Kjaer, Svend; Murray-Rust, Judith; Rosso, Enrico; Zambon, Alfonso; Scapozza, Leonardo; McDonald, Neil Q.; Lucchini, Vittorio; Gambacorti-Passerini, Carlo
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 4 p. 1482 - 1496
