2-甲氧基-6-硝基苯乙酸合成路线 （共 16 条）
反应条件
hydrogen; palladium 10 on activated carbon in acetic acid T=20°C; 16 h;
参考文献
US2004/106791 A1, ;
Page 11 ;
反应条件
1: palladium; acetic acid / Hydrogenation 2: methanol. sodium methylate / Behandeln des Reaktionsprodukts mit wss.Natronlauge 3: lithium alanate; diethyl ether View Scheme
参考文献
Cook et al.
Journal of the Chemical Society, 1952 , p. 3904,3909
反应条件
1: 97 percent / H2 / 10 percent Pd/C 2: 73 percent / 48 percent aq. HBr View Scheme
参考文献
Steffan, Robert J.; Ashwell, Mark A.; Solvibile, William R.; Matelan, Edward; Largis, Elwood; Han, Stella; Tillet, Jeffery; Mulvey, Ruth
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 20 p. 2957 - 2961
反应条件
hydrogenchloride; sulfuric acid
参考文献
Steffan, Robert J.; Ashwell, Mark A.; Solvibile, William R.; Matelan, Edward; Largis, Elwood; Han, Stella; Tillet, Jeffery; Mulvey, Ruth
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 20 p. 2957 - 2961
反应条件
1: 99 percent / aq. ethanol
2: 97 percent / aq. HCl; H2SO4
View Scheme
参考文献
Steffan, Robert J.; Ashwell, Mark A.; Solvibile, William R.; Matelan, Edward; Largis, Elwood; Han, Stella; Tillet, Jeffery; Mulvey, Ruth
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 20 p. 2957 - 2961
反应条件
1: NaOMe / methanol
2: (i) KOEt, Et2O, (ii) H2O2
View Scheme
参考文献
Beckett,A.H. et al.
Tetrahedron, 1968 , vol. 24, p. 6093 - 6109
反应条件
1: (i) NaNO2, aq. H2SO4, (ii) CuSO4
2: NaOMe / methanol
3: (i) KOEt, Et2O, (ii) H2O2
View Scheme
参考文献
Beckett,A.H. et al.
Tetrahedron, 1968 , vol. 24, p. 6093 - 6109
反应条件
sodium hydroxide; dihydrogen peroxide
参考文献
Blaikie; Perkin
Journal of the Chemical Society, 1924 , vol. 125, p. 313
反应条件
sulfuric acid; sodium nitrite
参考文献
Tomita; Hirai
Yakugaku Zasshi, 1957 , vol. 77, p. 290,292
Chem.Abstr., 1957 , p. 11362
反应条件
1: potassium ethylate; diethyl ether
2: hydrogen peroxide; NaOH-solution
View Scheme
参考文献
Blaikie; Perkin
Journal of the Chemical Society, 1924 , vol. 125, p. 313
