2,6-di-tert-butyl-4-methyl-phenol; potassium acetate; P(t-Bu)2(2'-methylbiphenyl-2-yl); palladium diacetate in ethylene glycol dimethyl ether; toluene T=100°C; 96 h;

1: 99 percent / Na2CO3 / Pd(PPh3)4 / toluene; ethanol; H2O / 96 h / 80 °C 2: 91 percent / BBr3 / CH2Cl2 / 8 h / 0 °C 3: 71 percent / 2-di-tert-butylphosphino-2'-methylbiphenyl; KOAc; 2,6-di-tert-butyl-4-methylphenol / Pd(OAc)2 / toluene; 1,2-dimethoxy-ethane / 96 h / 100 °C View Scheme

1: 99 percent / Na2CO3 / Pd(PPh3)4 / toluene; ethanol; H2O / 96 h / 80 °C 2: 91 percent / BBr3 / CH2Cl2 / 8 h / 0 °C 3: 71 percent / 2-di-tert-butylphosphino-2'-methylbiphenyl; KOAc; 2,6-di-tert-butyl-4-methylphenol / Pd(OAc)2 / toluene; 1,2-dimethoxy-ethane / 96 h / 100 °C View Scheme

1: 91 percent / BBr3 / CH2Cl2 / 8 h / 0 °C 2: 71 percent / 2-di-tert-butylphosphino-2'-methylbiphenyl; KOAc; 2,6-di-tert-butyl-4-methylphenol / Pd(OAc)2 / toluene; 1,2-dimethoxy-ethane / 96 h / 100 °C View Scheme

palladium diacetate in acetic acid 48 h; Heating;

palladium on activated charcoal T=230°C;

1: phosphorus (V)-oxide; phosphoric acid 2: palladium/charcoal / 230 °C View Scheme