1-溴-4-(异硫氰酸基甲基)苯合成路线 （共 5 条）
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; thiocarbonylation; 0.5 h;
参考文献
Windhorst, Albert D.; Timmerman, Henk; Worthington, Edward A.; Bijloo, Greetje J.; Nederkoorn, Paul H. J.; Menge, Wiro M. P. B.; Leurs, Rob; Herscheid, Jacobus D. M.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 9 p. 1754 - 1761
反应条件
1: With triethylamine in tetrahydrofuran T=20°C; 1.5 h; Cooling with ice; 2: With p-toluenesulfonyl chloride in tetrahydrofuran 1 h; Cooling with ice;
参考文献
Shanghai Institute of Materia Medica, Chinese Academy of Sciences; SHEN, Jianhua; WANG, Yiping; WANG, Kai
Patent: EP2725024 A1, 2014 ;
Location in patent: Paragraph 0339 ;
反应条件
1: tetrahydrofuran / 1 h / 22 °C 2: 97 percent / tosyl chloride / tetrahydrofuran / 1 h / 0 - 22 °C View Scheme
参考文献
Shah et al.
Journal of the Indian Chemical Society, 1956 , vol. 33, p. 423
反应条件
1: Amberlite IRA-400 (N3-form) 2: 2) benzene, reflux View Scheme
参考文献
Molina, Pedro; Alajarin, Mateo; Lopez-Leonardo, Carmen; Cano, Felix Hernandez; Llamas-Saiz, Antonio L.; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 2 p. 199 - 210
反应条件
2) benzene, reflux; Yield given. Multistep reaction;
参考文献
Molina, Pedro; Alajarin, Mateo; Lopez-Leonardo, Carmen; Cano, Felix Hernandez; Llamas-Saiz, Antonio L.; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 2 p. 199 - 210
