3-甲基苯并呋喃-2-甲酸甲酯合成路线 （共 21 条）
反应条件
acetyl chloride 17 h; Heating / reflux;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2006/10008 A1, 2006 ;
Location in patent: Page/Page column 167 ;
WO 2006/010008 A1
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in benzene 2 h; Ambient temperature;
参考文献
Saari, Walfred S.; Wai, John S.; Fisher, Thorsten E.; Thomas, Craig M.; Hoffman, Jacob M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3792 - 3802
反应条件
1: 3-Methyl-benzofuran-2-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide in tetrahydrofuran T=20°C; 1 h; 2: methanol With triethylamine in tetrahydrofuran T=20°C;
参考文献
AXYS PHARMACEUTICALS INC.
Patent: WO2004/92115 A2, 2004 ;
Location in patent: Page 75 ;
WO 2004/092115 A2
反应条件
triethylamine in tetrahydrofuran T=20°C;
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2005/118584 A2, 2005 ;
Location in patent: Page/Page column 80-81 ;
反应条件
[{(η5-C5Me5)RhCl}2(μ-Cl)2]; caesium acetate; acetic acid in dichloromethane T=20°C; 16 h; Reagent/catalyst;
参考文献
Liu, Guixia; Shen, Yangyang; Zhou, Zhi; Lu, Xiyan
Angewandte Chemie - International Edition, 2013 , vol. 52, # 23 p. 6033 - 6037
Angew. Chem., 2013 , vol. 125, # 23 p. 6149 - 6153,5
反应条件
[{(η5-C5Me5)RhCl}2(μ-Cl)2]; caesium acetate in methanol T=20°C; 16 h;
参考文献
Liu, Guixia; Shen, Yangyang; Zhou, Zhi; Lu, Xiyan
Angewandte Chemie - International Edition, 2013 , vol. 52, # 23 p. 6033 - 6037
Angew. Chem., 2013 , vol. 125, # 23 p. 6149 - 6153,5
反应条件
in diethyl ether 0.333333 h; Ambient temperature;
参考文献
Suzuki; Horaguchi; Shimizu; Abe
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 9 p. 2762 - 2767
反应条件
1: 1.4 percent / AcONa, Ac2O / 3 h / 110 °C 2: 93 percent / diethyl ether / 0.33 h / Ambient temperature View Scheme
参考文献
Suzuki; Horaguchi; Shimizu; Abe
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 9 p. 2762 - 2767
反应条件
methanol T=160°C; im Druckrohr;
参考文献
Peters; Simonis
Chemische Berichte, 1908 , vol. 41, p. 831
反应条件
1: sodium carbonate / ethyl acetate; water / 2 h / 0 °C 2: [{(η5-C5Me5)RhCl}2(μ-Cl)2]; caesium acetate; acetic acid / dichloromethane / 16 h / 20 °C View Scheme
参考文献
Liu, Guixia; Shen, Yangyang; Zhou, Zhi; Lu, Xiyan
Angewandte Chemie - International Edition, 2013 , vol. 52, # 23 p. 6033 - 6037
Angew. Chem., 2013 , vol. 125, # 23 p. 6149 - 6153,5
