4,5-二甲氧基-2-甲基苯甲酸合成路线 （共 15 条）
反应条件
sodium chlorite; sodium dihydrogenphosphate in water; dimethyl sulfoxide
T=20°C;
参考文献
Le, Thanh Nguyen; Cho, Won-Jea
Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 7 p. 1026 - 1029
反应条件
1: With sodium hydroxide; bromine in 1,4-dioxane; water
T=0 - 20°C;
2: With sodium hydrogensulfite in 1,4-dioxane; water
T=20°C; 18 h;
参考文献
Kim, Joa Kyum; Kim, Young Ha; Nam, Ho Tae; Kim, Bum Tae; Heo, Jung-Nyoung
Organic Letters, 2008 , vol. 10, # 16 p. 3543 - 3546
反应条件
1: 1-Bromo-3,4-dimethoxy-6-methylbenzene With tert.-butyl lithium in tetrahydrofuran
T=-78°C; 1 h;
2: carbon dioxide in tetrahydrofuran
Further stages.;
参考文献
Fukuda, Tsutomu; Iwao, Masatomo
Heterocycles, 2007 , vol. 74, # C p. 701 - 720
反应条件
1: AlCl3; HCl / 40 °C / Behandlung des Reaktionsprodukts mit Eis und verd.Salzsaeure
2: aqueous potassium permanganate
View Scheme
参考文献
Perkin; Weizmann
Journal of the Chemical Society, 1906 , vol. 89, p. 1651
反应条件
1: 3,4-dimethoxy-benzoic acid With n-butyllithium; potassium tert-butylate in tetrahydrofuran; hexane
T=-78 - -50°C; 2 h;
2: methyl iodide in tetrahydrofuran; hexane
T=-78 - 20°C; Further stages.;
参考文献
Chau, Nguyet Trang Thanh; Nguyen, Thi Huu; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Tetrahedron, 2008 , vol. 64, # 46 p. 10552 - 10557
反应条件
1: sec.-butyllithium; 3,4-dimethoxy-benzoic acid With N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexane; cyclohexane
T=-78 - -30°C; 2 h;
2: methyl iodide in tetrahydrofuran; hexane; cyclohexane
T=-30 - 20°C; Further stages.;
参考文献
Chau, Nguyet Trang Thanh; Nguyen, Thi Huu; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Tetrahedron, 2008 , vol. 64, # 46 p. 10552 - 10557
反应条件
1: (i) AgCl, H2O, (ii) Na-Hg
2: (i) aq. OsO4, THF, (ii) NaIO4
3: Ag2O / aq. NH3
View Scheme
参考文献
Olesch; Boehm
Archiv der Pharmazie, 1972 , vol. 305, # 3 p. 222 - 229
反应条件
potassium permanganate
参考文献
Gattermann
Justus Liebigs Annalen der Chemie, 1907 , vol. 357, p. 373
Full Text Show Details
Perkin; Weizmann
Journal of the Chemical Society, 1906 , vol. 89, p. 1651
参考文献
Luff; Perkin; Robinson
Journal of the Chemical Society, 1910 , vol. 97, p. 1139
反应条件
1: NaOH-solution
2: AlCl3; HCl / 40 °C / Behandlung des Reaktionsprodukts mit Eis und verd.Salzsaeure
3: aqueous potassium permanganate
View Scheme
参考文献
Perkin; Weizmann
Journal of the Chemical Society, 1906 , vol. 89, p. 1651
