2-(4-溴苄基)丙烯酸乙酯合成路线 （共 7 条）
反应条件
formaldehyd; potassium carbonate in diethyl ether; water
参考文献
Institut National de la Sante et de la Recherche Medicale (Inserm)
Patent: US6518260 B1, 2003 ;
反应条件
1: (4-bromophenyl)dichloroborane With i -Pr2Zn in diethyl ether T=25°C; 2 h; 2: in tetrahydrofuran T=-30°C; 0.166667 h; 3: 2-(bromomethyl)propenoic acid ethyl ester in tetrahydrofuran T=20°C; Further stages.;
参考文献
Hupe, Eike; Calaza, M. Isabel; Knochel, Paul
Chemical Communications, 2002 , # 13 p. 1390 - 1391
参考文献
Institut National de la Sante et de la Recherche Medicale (Inserm)
Patent: US6518260 B1, 2003 ;
反应条件
[Cu(I)(CH3CN)4]PF6; N-ethyl-N,N-diisopropylamine in acetonitrile T=20°C; 16 h; Inert atmosphereSchlenk techniqueIrradiation;
参考文献
Baralle, Alexandre; Fensterbank, Louis; Goddard, Jean-Philippe; Ollivier, Cyril
Chemistry - A European Journal, 2013 , vol. 19, # 33 p. 10809 - 10813
反应条件
potassium carbonate T=100°C; Wittig reaction; 3 h;
参考文献
Chen, Huixiong; Noble, Florence; Mothe, Aurelie; Meudal, Herve; Coric, Pascale; Danascimento, Sophie; Roques, Bernard P.; George, Pascal; Fournie-Zaluski, Marie-Claude
Journal of Medicinal Chemistry, 2000 , vol. 43, # 7 p. 1398 - 1408
反应条件
1.1: BCl3 / CH2Cl2 / 10 h / 25 °C 2.1: Br2 / 16 h / 25 °C 3.1: i-Pr2Zn / diethyl ether / 2 h / 25 °C 3.2: CuCN*2LiCl / tetrahydrofuran / 0.17 h / -30 °C 3.3: 62 percent / tetrahydrofuran / 20 °C View Scheme
参考文献
Hupe, Eike; Calaza, M. Isabel; Knochel, Paul
Chemical Communications, 2002 , # 13 p. 1390 - 1391
反应条件
1.1: Br2 / 16 h / 25 °C 2.1: i-Pr2Zn / diethyl ether / 2 h / 25 °C 2.2: CuCN*2LiCl / tetrahydrofuran / 0.17 h / -30 °C 2.3: 62 percent / tetrahydrofuran / 20 °C View Scheme
参考文献
Hupe, Eike; Calaza, M. Isabel; Knochel, Paul
Chemical Communications, 2002 , # 13 p. 1390 - 1391
