5-氯-4-硝基-2,1,3-苯并硒二唑合成路线 （共 8 条）
反应条件
sulfuric acid; nitric acid in water T=0 - 5°C; 2 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/6533 A2, 2007 ;
Location in patent: Page/Page column 42-43 ;
反应条件
1: 66 percent / SeO2 2: 90 percent / NaNO3; aq. H2SO4 / 100 °C View Scheme
参考文献
Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379
反应条件
sulfuric acid; nitric acid T=4°C; 2 h;
参考文献
Tian, Wei; Grivas, Spiros; Olsson, Kjell
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 2 p. 257 - 262
反应条件
1: SnCl2*2H2O 2: SeO2 3: KNO3, H2SO4 View Scheme
参考文献
Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379
反应条件
1: H2; Raney nickel / propan-2-ol 2: 66 percent / SeO2 3: 90 percent / NaNO3; aq. H2SO4 / 100 °C View Scheme
参考文献
Rtishchev; Selitrennikov
Russian Journal of General Chemistry, 2004 , vol. 74, # 3 p. 428 - 437
反应条件
hydrogenchloride; hydrogen iodide in water T=20°C; 2 h;
参考文献
Teague, Simon J.; Barber, Simon; King, Sarah; Stein, Linda
Tetrahedron Letters, 2005 , vol. 46, # 27 p. 4613 - 4616
反应条件
1: 93 percent / 2-methoxy-ethanol; H2O / 0.17 h / Heating 2: 80 percent / 40percent aq. NH4SH / methanol / 3 h / Heating 3: methanol; H2O / 3 h / Heating View Scheme
参考文献
Grivas, Spiros; Tian, Wei; Ronne, Erik; Lindstroem, Stefan; Olsson, Kjell
Acta Chemica Scandinavica, 1993 , vol. 47, # 5 p. 521 - 528
反应条件
1: 93 percent / 2-methoxy-ethanol; H2O / 0.17 h / Heating
2: 80 percent / 40percent aq. NH4SH / methanol / 3 h / Heating
3: aq. KOH / methanol / 3 h / Heating
View Scheme
参考文献
Grivas, Spiros; Tian, Wei; Ronne, Erik; Lindstroem, Stefan; Olsson, Kjell
Acta Chemica Scandinavica, 1993 , vol. 47, # 5 p. 521 - 528
