3-(4-硝基苯基)-1-丙醇合成路线 （共 17 条）
反应条件
1H-imidazole; iodine; triphenylphosphine in toluene T=20°C; 3 h; Inert atmosphere;
参考文献
Pinto, Orlando; Sardinha, Joao; Vaz, Pedro D.; Piedade, Fatima; Calhorda, Maria J.; Abramovitch, Rudolph; Nazareth, Nair; Pinto, Madalena; Nascimento, Maria S. J.; Rauter, Amelia P.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 9 p. 3175 - 3187
反应条件
1: pyridine / CHCl3 / 16 h / Ambient temperature 2: 85 percent / dioxane / 3 h / 90 - 100 °C View Scheme
参考文献
Katakami; Yokoyama; Miyamoto; Mori; Kawauchi; Nobori; San-nohe; Kaiho; Kamiya
Journal of Medicinal Chemistry, 1992 , vol. 35, # 18 p. 3325 - 3330
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
RIB-X-PHARMACEUTICALS, INC.
Patent: WO2008/106204 A1, 2008 ;
Location in patent: Page/Page column 118-119 ;
反应条件
1: pyridine / CHCl3 / 16 h / Ambient temperature 2: 85 percent / dioxane / 3 h / 90 - 100 °C 3: 1.) NaOH, 2.) p-toluenesulfonic acid monohydrate / 1.) methanol, 50 deg C, 2.) 80 deg C, 1 h View Scheme
参考文献
Katakami; Yokoyama; Miyamoto; Mori; Kawauchi; Nobori; San-nohe; Kaiho; Kamiya
Journal of Medicinal Chemistry, 1992 , vol. 35, # 18 p. 3325 - 3330
反应条件
borane-THF in tetrahydrofuran
T=20°C; 1 h;
参考文献
Pinto, Orlando; Sardinha, Joao; Vaz, Pedro D.; Piedade, Fatima; Calhorda, Maria J.; Abramovitch, Rudolph; Nazareth, Nair; Pinto, Madalena; Nascimento, Maria S. J.; Rauter, Amelia P.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 9 p. 3175 - 3187
反应条件
1: With potassium tert-butylate; copper (II) acetate monohydrate; 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride; tert-butyl alcohol in toluene
T=25°C; 25 h; Inert atmosphere;
2: With tetrabutyl ammonium fluoride in tetrahydrofuran; toluene
T=0°C;
参考文献
Wang, Guang-Hui; Bin, Huai-Yu; Sun, Miao; Chen, Shu-Wei; Liu, Ji-Hong; Zhong, Chong-Min
Tetrahedron, 2014 , vol. 70, # 12 p. 2175 - 2179
反应条件
hydrogen in methanol
T=20°C; P=760.051 Torr; 24 h;
参考文献
Maegawa, Tomohiro; Takahashi, Tohru; Yoshimura, Masatoshi; Suzuka, Hiroyasu; Monguchi, Yasunari; Sajiki, Hironao
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 13 p. 2091 - 2095
反应条件
sodium hydrogencarbonate; sodium carbonate in methanol hydrogen chloride; chloroform; water
参考文献
Sanofi
Patent: US4720581 A1, 1988 ;
反应条件
silver nitrate in 1,4-dioxane; water
T=45°C; 2 h;
参考文献
Blankespoor, Ronald L.; DeVries, Tim; Hansen, Eric; Kallemeyn, Jeffrey M.; Klooster, Aaron M.; Mulder, Jason A.; Smart, Robert P.; Vander Griend, Douglas A.
Journal of Organic Chemistry, 2002 , vol. 67, # 8 p. 2677 - 2681
反应条件
lithium borohydride; 1-n-decene in tetrahydrofuran
T=20°C; 18 h; Inert atmosphere;
参考文献
Pinto, Orlando; Sardinha, Joao; Vaz, Pedro D.; Piedade, Fatima; Calhorda, Maria J.; Abramovitch, Rudolph; Nazareth, Nair; Pinto, Madalena; Nascimento, Maria S. J.; Rauter, Amelia P.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 9 p. 3175 - 3187
