5-硝基苯并[b]噻吩-2-羧酸甲酯合成路线 （共 22 条）
反应条件
1: lithium hydroxide / tetrahydrofuran / 16 h / 20 °C
2: benzotriazol-1-ol; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C
3: hydrogen / Pd/C / methanol / 4 h / 20 °C / 2068.59 Torr
4: lithium aluminium tetrahydride / tetrahydrofuran / 20 h / Heating
View Scheme
参考文献
Tavares, Francis X.; Al-Barazanji, Kamal A.; Bishop, Michael J.; Britt, Christy S.; Carlton, David L.; Cooper, Joel P.; Feldman, Paul L.; Garrido, Dulce M.; Goetz, Aaron S.; Grizzle, Mary K.; Hertzog, Donald L.; Ignar, Diane M.; Lang, Daniel G.; McIntyre, Maggie S.; Ott, Ronda J.; Peat, Andrew J.; Zhou, Hui-Qiang
Journal of Medicinal Chemistry, 2006 , vol. 49, # 24 p. 7108 - 7118
反应条件
1: lithium hydroxide / tetrahydrofuran / 16 h / 20 °C
2: benzotriazol-1-ol; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C
View Scheme
参考文献
Tavares, Francis X.; Al-Barazanji, Kamal A.; Bishop, Michael J.; Britt, Christy S.; Carlton, David L.; Cooper, Joel P.; Feldman, Paul L.; Garrido, Dulce M.; Goetz, Aaron S.; Grizzle, Mary K.; Hertzog, Donald L.; Ignar, Diane M.; Lang, Daniel G.; McIntyre, Maggie S.; Ott, Ronda J.; Peat, Andrew J.; Zhou, Hui-Qiang
Journal of Medicinal Chemistry, 2006 , vol. 49, # 24 p. 7108 - 7118
