1-(1-甲基-4-哌啶基)-乙酮合成路线 （共 15 条）
反应条件
sodium hydroxide; formaldehyd; formic acid in water
参考文献
Rhone-Poulenc Sante
Patent: US4960779 A1, 1990 ;
反应条件
hydrogen; platinum(IV) oxide in ethanol T=70°C; 7 h; Yield given. Yields of byproduct given;
参考文献
Kuznetsov, S. G.; Libman, N. M.; Gorchakov, V. S.; Golikov, S. N.; Zatsepin, E. P.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 4 p. 253 - 258
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 4 p. 435 - 440
反应条件
1: 81 percent / NaBH4 / methanol / 0.5 h / 21 °C 2: 17 percent / H2 / PtO2 / acetic acid / 18 h / 21 °C / 2327.2 Torr 3: 27 percent / CrO3 / acetic acid View Scheme
参考文献
Waters; Spivak; Hermsmeier; Yadav; Liang; Gund
Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 545 - 554
反应条件
1: 17 percent / H2 / PtO2 / acetic acid / 18 h / 21 °C / 2327.2 Torr 2: 27 percent / CrO3 / acetic acid View Scheme
参考文献
Waters; Spivak; Hermsmeier; Yadav; Liang; Gund
Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 545 - 554
反应条件
chromium(VI) oxide in acetic acid
参考文献
Waters; Spivak; Hermsmeier; Yadav; Liang; Gund
Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 545 - 554
反应条件
1: 97 percent / acetone 2: H2 / PtO2 / aq. ethanol / 7 h / 70 °C View Scheme
参考文献
Kuznetsov, S. G.; Libman, N. M.; Gorchakov, V. S.; Golikov, S. N.; Zatsepin, E. P.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 4 p. 253 - 258
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 4 p. 435 - 440
反应条件
1: 48 percent 2: 97 percent / acetone 3: H2 / PtO2 / aq. ethanol / 7 h / 70 °C View Scheme
参考文献
Kuznetsov, S. G.; Libman, N. M.; Gorchakov, V. S.; Golikov, S. N.; Zatsepin, E. P.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 4 p. 253 - 258
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 4 p. 435 - 440
反应条件
1: methanol / Hydrieren des Reaktionsgemisches an Raney-Nickel 2: SOCl2; benzene 3: diethyl ether / Behandeln des Reaktionsprodukts in Benzol mit wss. Salzsaeure View Scheme
参考文献
Grob; Renk
Helvetica Chimica Acta, 1954 , vol. 37, p. 1672,1676
反应条件
1: acetone 2: Raney nickel; methanol; triethylamine / 90 °C / 73550.8 Torr / Hydrogenation 3: NH3; methanol 4: SOCl2; benzene 5: diethyl ether / Behandeln des Reaktionsprodukts in Benzol mit wss. Salzsaeure View Scheme
参考文献
Grob; Renk
Helvetica Chimica Acta, 1954 , vol. 37, p. 1672,1676
反应条件
1: NH3; methanol 2: SOCl2; benzene 3: diethyl ether / Behandeln des Reaktionsprodukts in Benzol mit wss. Salzsaeure View Scheme
参考文献
Grob; Renk
Helvetica Chimica Acta, 1954 , vol. 37, p. 1672,1676
