N,N-二(2-氯乙基)苯-1,4-二胺合成路线 （共 8 条）
反应条件
in diethyl ether
1 h;
参考文献
Poplavskaya, I. A.; Kurmangalieva, R. G.; Khalilova, S. F.; Abdullin, K. A.; Kudrina, I. K.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 4 p. 231 - 235
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 4 p. 16 - 21
反应条件
triethylamine in dichloromethane
0.25 h;
参考文献
Niculescu-Duvaz, Dan; Niculescu-Duvaz, Ion; Friedlos, Frank; Martin, Janet; Spooner, Robert; Davies, Lawrence; Marais, Richard; Springer, Caroline J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 26 p. 5297 - 5309
反应条件
triethylamine in 1,4-dioxane
5 h; Heating;
参考文献
Baraldi; Cacciari; Moro; Romagnoli; Ji; Jacobson; Gessi; Borea; Spalluto
Journal of Medicinal Chemistry, 2001 , vol. 44, # 17 p. 2735 - 2742
反应条件
1: toluene
2: KOH
View Scheme
参考文献
Benn,M.H. et al.
Journal of the Chemical Society, 1961 , p. 2365 - 2375
反应条件
triethylamine in N,N-dimethyl-formamide
参考文献
Tala, Satishkumar D.; Ou, Tai-Hsin; Lin, Yi-Wen; Tala, Kiranben S.; Chao, Shu-Hsin; Wu, Ming-Hsi; Tsai, Tung-Hu; Kakadiya, Rajesh; Suman, Sharda; Chen, Ching-Huang; Lee, Te-Chang; Su, Tsann-Long
European Journal of Medicinal Chemistry, 2014 , vol. 76, p. 155 - 169
反应条件
1: 1.) N-methylmorpholine, isobutyl chloroformate, 2.) N-methylmorpholine / 1.) THF, -15 - -10 deg, 15 min., 2.) THF, DMF, a) -15 - -10 deg, 2h, b) RT, overnight
2: 94 percent / CH2Cl2 / 0.5 h / Ambient temperature
View Scheme
参考文献
Chakravarty; Carl; Weber; Katzenellenbogen
Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 633 - 638
反应条件
<b>Multi-step reaction with 4 steps<br /> </b>1: 96 percent / dimethylsulfoxide / 3.5 h / Heating<br />2: Et<sub>3</sub>N / tetrahydrofuran; CH<sub>2</sub>Cl<sub>2</sub> / 0.17 h / 0 °C<br />3: LiCl / dimethylformamide / 0.08 h / Heating<br />4: 88 percent / SnCl<sub>2</sub>*H<sub>2</sub>O; HCl / H<sub>2</sub>O / 1 h / Heating<br /> <br />
参考文献
Ferlin; Via, L. Dalla; Gia Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 4 p. 771 - 777
反应条件
<b>Multi-step reaction with 3 steps<br /> </b>1: 30 percent / acetic acid / H<sub>2</sub>O / 0 - 20 °C<br />2: 86 percent / pyridine; thionyl chloride / CH<sub>2</sub>Cl<sub>2</sub> / 1 h / Heating<br />3: hydrogen / 10 percent Pd/C / ethanol / 12 h<br /> <br />
参考文献
Jordan, Allan M; Khan, Tariq H; Malkin, Hugh; Osborn, Helen M I Bioorganic and medicinal chemistry, 2002 , vol. 10, # 8 p. 2625 - 2633
