4-（2-酮酸-1-苯并咪唑）哌啶合成路线 （共 20 条）
反应条件
trifluoroacetic acid in dichloromethane T=0°C; 1 h;
参考文献
Synthetic Communications, , vol. 43, # 13 p. 1796 - 1801
反应条件
in chloroform; ethyl acetate
参考文献
US5760054 A1, ;
US 5760054 A
反应条件
1: Zn; aq. HCl / methanol / 50 °C 2: acetonitrile 3: aq. NaOH / 100 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 19 p. 5052 - 5056
反应条件
1: dimethylformamide / 60 °C 2: NH4HCO2 / Pt/C / ethanol / 20 °C 3: Et3N / CH2Cl2 / 20 °C 4: aq. NaOH / ethanol / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 6 p. 1687 - 1691
反应条件
sodium hydroxide in ethanol Heating;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 6 p. 1687 - 1691
反应条件
1: acetonitrile 2: aq. NaOH / 100 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 19 p. 5052 - 5056
反应条件
1.1: acetic acid / dichloromethane / 0.25 h / 0 °C 1.2: 16 h / 0 - 20 °C 2.1: dichloromethane / 0.5 h / 0 - 20 °C 3.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C View Scheme
参考文献
Synthetic Communications, , vol. 43, # 13 p. 1796 - 1801
反应条件
1.1: acetic acid / dichloromethane / 0.25 h / 0 °C 1.2: 16 h / 0 - 20 °C 2.1: dichloromethane / 0.5 h / 0 - 20 °C 3.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C View Scheme
参考文献
Synthetic Communications, , vol. 43, # 13 p. 1796 - 1801
反应条件
1: dichloromethane / 0.5 h / 0 - 20 °C 2: trifluoroacetic acid / dichloromethane / 1 h / 0 °C View Scheme
参考文献
Synthetic Communications, , vol. 43, # 13 p. 1796 - 1801
反应条件
sodium carbonate; potassium iodide in 4-hydroxymethyl-1,3-dioxolane T=80°C; 7 h;
参考文献
INSTITUT UNIVERSITARI DE CIENCIA I TECNOLOGIA
Patent: WO2008/80601 A2, 2008 ;
Location in patent: Page/Page column 10-11 ;
