4-(2-呋喃基)嘧啶-2-胺合成路线 （共 7 条）
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=100°C; 21 h;
参考文献
Eisai Co., Ltd.
Patent: EP1439175 A1, 2004 ;
Location in patent: Page 46 ;
反应条件
sodium hydride in N,N-dimethyl-formamide T=100°C;
参考文献
Gupton, John T.; Petrich, Scott A.; Hicks, Fred A.; Wilkinson, Doug R.; Vargas, Marian; Hosein, Kirsten N.; Sikorski, James A.
Heterocycles, 1998 , vol. 47, # 2 p. 689 - 702
反应条件
sodium hydroxide in butan-1-ol 12 h; Inert atmosphereSchlenk techniqueReflux;
参考文献
Liu, Yi-Feng; Wang, Cui-Ling; Bai, Ya-Jun; Han, Ning; Jiao, Jun-Ping; Qi, Xiao-Li
Organic Process Research and Development, 2008 , vol. 12, # 3 p. 490 - 495
参考文献
Santra, Subhankar; Dhara, Kalyan; Ranjan, Priyadarshi; Bera, Parthasarathi; Dash, Jyotirmayee; Mandal, Swadhin K.
Green Chemistry, 2011 , vol. 13, # 11 p. 3238 - 3247
反应条件
1: 94 percent / dimethylformamide / Heating 2: 1.) POCl3, 2.) NaPF6 / 1.) CH2Cl2, rt, 30 min, 2.) MeOH, 0 deg C 3: 76 percent / NaOEt / ethanol / Ambient temperature 4: 78 percent / NaH / dimethylformamide / 100 °C View Scheme
参考文献
Liu, Yi-Feng; Wang, Cui-Ling; Bai, Ya-Jun; Han, Ning; Jiao, Jun-Ping; Qi, Xiao-Li
Organic Process Research and Development, 2008 , vol. 12, # 3 p. 490 - 495
反应条件
1: 1.) POCl3, 2.) NaPF6 / 1.) CH2Cl2, rt, 30 min, 2.) MeOH, 0 deg C 2: 76 percent / NaOEt / ethanol / Ambient temperature 3: 78 percent / NaH / dimethylformamide / 100 °C View Scheme
参考文献
Gupton, John T.; Petrich, Scott A.; Hicks, Fred A.; Wilkinson, Doug R.; Vargas, Marian; Hosein, Kirsten N.; Sikorski, James A.
Heterocycles, 1998 , vol. 47, # 2 p. 689 - 702
反应条件
1: triethylamine / acetonitrile / 12 h / Inert atmosphere 2: methanol / Reflux View Scheme
参考文献
Santra, Subhankar; Dhara, Kalyan; Ranjan, Priyadarshi; Bera, Parthasarathi; Dash, Jyotirmayee; Mandal, Swadhin K.
Green Chemistry, 2011 , vol. 13, # 11 p. 3238 - 3247
