5-溴-2-氯-m-二甲苯合成路线 （共 3 条）
反应条件
1: With hydrogenchloride; sodium nitrite in water T=0°C; 0.333333 h; 2: With hydrogenchloride; copper(l) chloride in water T=20 - 70°C; 16 h;
参考文献
Japan Polypropylene Corporation; NAKANO, Masato; UCHINO, Hideshi; IWAMA, Naoshi; KASHIMOTO, Masami; KATO, Tomohiro
Patent: EP2360163 A1, 2011 ;
Location in patent: Paragraph 0246-0247 ;
反应条件
1: With hydrogenchloride; sodium nitrite in water T=0°C; 0.333333 h; 2: With hydrogenchloride; copper(l) chloride in water T=20 - 70°C; 17 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2005/92880 A1, 2005 ;
Location in patent: Page/Page column 178-179 ;
WO 2005/092880 A1
反应条件
1: 5-bromo-2-chloro-1,3-dimethylbenzene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.166667 h; Inert atmosphere;
2: carbon dioxide in tetrahydrofuran; hexane
T=-78°C;
3: With hydrogenchloride; water in tetrahydrofuran; hexane
参考文献
Asahi Kasei Pharma Corporation
Patent: US2009/298894 A1, 2009 ;
Location in patent: Page/Page column 45 ;
US 20090298894 A1
