5-甲基-3-苯基-4-异噁唑羧酸甲酯合成路线 （共 15 条）
反应条件
triethylamine in ethanol
参考文献
Green, Jeremy; Bemis, Guy; Grillot, Anne-Laure; Ledeboer, Mark; Salituro, Francesco G.; Harrington, Edmund; Gao, Huai; Baker, Christopher; Cao, Jingrong; Hale, Michael
Patent: US2003/149051 A1, 2003 ;
反应条件
dicyclohexyl-carbodiimide in methanol 24 h; Ambient temperature;
参考文献
Kijima, Masashi; Nambu, Yoko; Endo, Takeshi
Journal of Organic Chemistry, 1985 , vol. 50, # 7 p. 1140 - 1142
反应条件
triethylamine in benzene T=70°C; 2 h; Microwave irradiation; regioselective reaction;
参考文献
Lasri, Jamal; Mukhopadhyay, Suman; Charmier, M. Adilia Januario
Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 5 p. 1385 - 1389
反应条件
1: acetoacetic acid methyl ester With sodium methylate in methanol 2: N-hydroxybenzenecarboximidoyl chloride in methanol T=0°C; 4 h;
参考文献
Synthesis, , # 9 p. 1347 - 1356
反应条件
1.1: hydroxylammonium sulfate / methanol / 0.5 h 1.2: 0.5 h / pH 8 - 9 / Reflux 2.1: chlorine / methanol / 0 - 5 °C 3.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10 3.2: 2 h / 0 - 20 °C / pH 9 View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 49, # 3 p. 621 - 627
反应条件
1.1: chlorine / methanol / 0 - 5 °C 2.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10 2.2: 2 h / 0 - 20 °C / pH 9 View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 49, # 3 p. 621 - 627
反应条件
triethylamine in diethyl ether
参考文献
Chemische Berichte, , vol. 106, p. 3275 - 3290
反应条件
triethylamine in diethyl ether 24 h; Ambient temperature;
参考文献
Bulletin de la Societe Chimique de France, , vol. <II>, p. 415 - 427
参考文献
Pharmaceutical Chemistry Journal, , # 11 p. 633 - 634
Khimiko-Farmatsevticheskii Zhurnal, , # 11 p. 29 - 31
反应条件
1: 100 percent / LiAlH4 / diethyl ether / 1 h / 40 °C 2: PCC / CH2Cl2 / 0.5 h / 20 °C View Scheme
参考文献
Roy, Amrendra K.; Batra, Sanjay
Synthesis, 2003 , # 9 p. 1347 - 1356
